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• W2113243517 abstract "Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are not normally generated during virus replication, but are associated instead with the presence of defective interfering (DI) viruses. We demonstrate here that DIs of paramyxoviruses, including parainfluenza virus 5, mumps virus and Sendai virus, can activate the IFN-induction cascade and the IFN-β promoter in the absence of virus protein synthesis. As virus protein synthesis is an absolute requirement for paramyxovirus genome replication, our results indicate that these DI viruses do not require replication to activate the IFN-induction cascade." @default.
• W2113243517 created "2016-06-24" @default.
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• W2113243517 date "2012-02-01" @default.
• W2113243517 modified "2023-09-26" @default.
• W2113243517 title "Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis" @default.
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• W2113243517 doi "https://doi.org/10.1099/vir.0.037531-0" @default.
• W2113243517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3352343" @default.
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