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• W2113243910 abstract "The current study was carried out to investigate the possible involvement of the L-arginine/nitric oxide/cyclic guanosine monophosphate (L-arginine/NO/cGMP) pathway in the aqueous extract of Corchorus olitorius. L. (Tiliaceae) (AECO) antinociception in mice, assessed by the abdominal constriction test. The AECO, obtained by soaking the dried leaves in distilled water (dH2O) (1:2; w/v) for 24 h, was prepared at concentrations of 10%, 50%, and 100% and administered subcutaneously (s.c.) 5 min after pretreatment (s.c.) of mice with dH2O, L-arginine (20 mg/kg), L-NAME (20 mg/kg), and methylene blue (MB) (20 mg/kg), respectively. AECO was found to exhibit concentration-independent antinociception with 100% AECO showing total loss of activity. Pretreatment with 20 mg/kg L-arginine, 20 mg/kg N.G-nitro-L-arginine methyl esters (L-NAME), or 20 mg/kg methylene blue (MB) was found to enhance the 50% AECO antinociception while significantly improving the ineffective 10% and 100% AECO antinociception. Meanwhile, L-arginine reversed, MB enhanced, and L-NAME produced insignificant changed in 10 mg/kg acetylsalicylic acid (ASA) antinocieption. Cotreatment with L-NAME, significantly (p < 0.05) reversed the L-arginine effect only on 100% AECO antinociception. However, the antinociceptive activity was still maintained. Cotreatment with MB, on the other hand, suppressed the L-arginine effect on ASA and 10% AECO while increasing its effect on the 50% and 100% AECO. In conclusion, this study has demonstrated the involvement of the L-arginine/NO/cGMP pathway in AECO antinociception." @default.
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• W2113243910 date "2006-01-01" @default.
• W2113243910 modified "2023-09-26" @default.
• W2113243910 title "Effects ofL-Arginine,L-NAME, Methylene Blue, and Their Combinations onCorchorus olitorius. Aqueous Extract Antinociception in Mice" @default.
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• W2113243910 doi "https://doi.org/10.1080/13880200600798478" @default.
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