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• W2113244148 abstract "There are great concerns about the increasing incidence of abnormalities in male reproductive function. Human sperm counts have markedly dropped and the rate of testicular cancer has clearly augmented over the past four decades. Moreover, the prevalence rates of cryptorchidism and hypospadias are also probably increasing. It has been hypothesized that all these adverse trends in male reproduction result from abnormalities in the development of the testis during foetal and neonatal life. Furthermore, many recent epidemiological, clinical and experimental data suggest that these male reproductive disorders could be due to the effects of xenobiotics termed endocrine disruptors, which are becoming more and more concentrated and prevalent in our environment. Among these endocrine disruptors, we chose to focus this review on the phthalates for different reasons: 1) they are widespread in the environment; 2) their concentrations in many human biological fluids have been measured; 3) the experimental data using rodent models suggesting a reprotoxicity are numerous and are the most convincing; 4) their deleterious effects on the in vivo and in vitro development and function of the rat foetal testis have been largely studied; 5) some epidemiological data in humans suggest a reprotoxic effect at environmental concentrations at least during neonatal life. However, the direct effects of phthalates on human foetal testis have never been explored. Thus, as we did for the rat in the 1990s, we recently developed and validated an organ culture system which allows maintenance of the development of the different cell types of human foetal testis. In this system, addition of 10-4 M MEHP (mono-2-ethylhexyl phthalate), the most produced phthalate, had no effect on basal or LH-stimulated production of testosterone, but it reduced the number of germ cells by increasing their apoptosis, without modification of their proliferation. This is the first experimental demonstration that phthalates alter the development of the foetal testis in humans. Using our organotypic culture system, we and others are currently investigating the effect of MEHP in the mouse and the rat, and it will be interesting to compare the results between these species to analyse the relevance of toxicological tests based on rodent models." @default.
• W2113244148 created "2016-06-24" @default.
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• W2113244148 date "2010-01-14" @default.
• W2113244148 modified "2023-09-25" @default.
• W2113244148 title "Adverse effects of endocrine disruptors on the foetal testis development: focus on the phthalates." @default.
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• W2113244148 cites W1972270992 @default.
• W2113244148 cites W1973102900 @default.
• W2113244148 cites W1974172315 @default.
• W2113244148 cites W1974233507 @default.
• W2113244148 cites W1974321365 @default.
• W2113244148 cites W1975781303 @default.
• W2113244148 cites W1979666006 @default.
• W2113244148 cites W1981079183 @default.
• W2113244148 cites W1988772913 @default.
• W2113244148 cites W1989517537 @default.
• W2113244148 cites W1989914657 @default.
• W2113244148 cites W1992906127 @default.
• W2113244148 cites W1993692364 @default.
• W2113244148 cites W1993833615 @default.
• W2113244148 cites W1996995976 @default.
• W2113244148 cites W1997134820 @default.
• W2113244148 cites W2002958599 @default.
• W2113244148 cites W2003163696 @default.
• W2113244148 cites W2014287839 @default.
• W2113244148 cites W2019372118 @default.
• W2113244148 cites W2023822954 @default.
• W2113244148 cites W2023955385 @default.
• W2113244148 cites W2027706074 @default.
• W2113244148 cites W2028528809 @default.
• W2113244148 cites W2033224797 @default.
• W2113244148 cites W2035758285 @default.
• W2113244148 cites W2038397637 @default.
• W2113244148 cites W2040462127 @default.
• W2113244148 cites W2041846642 @default.
• W2113244148 cites W2045525504 @default.
• W2113244148 cites W2048401878 @default.
• W2113244148 cites W2048830746 @default.
• W2113244148 cites W2049629759 @default.
• W2113244148 cites W2050439992 @default.
• W2113244148 cites W2050924985 @default.
• W2113244148 cites W2051448662 @default.
• W2113244148 cites W2054490657 @default.
• W2113244148 cites W2056618157 @default.
• W2113244148 cites W2058759573 @default.
• W2113244148 cites W2061188705 @default.
• W2113244148 cites W2062614245 @default.
• W2113244148 cites W2063646727 @default.
• W2113244148 cites W2068500779 @default.
• W2113244148 cites W2071684520 @default.
• W2113244148 cites W2083690559 @default.
• W2113244148 cites W2092148372 @default.
• W2113244148 cites W2095279324 @default.
• W2113244148 cites W2097633545 @default.
• W2113244148 cites W2097972057 @default.
• W2113244148 cites W2103191975 @default.
• W2113244148 cites W2104434742 @default.
• W2113244148 cites W2106532865 @default.
• W2113244148 cites W2112496192 @default.
• W2113244148 cites W2115176705 @default.
• W2113244148 cites W2122693798 @default.
• W2113244148 cites W2123654525 @default.
• W2113244148 cites W2127150492 @default.
• W2113244148 cites W2131393153 @default.
• W2113244148 cites W2134465607 @default.
• W2113244148 cites W2135358455 @default.
• W2113244148 cites W2141698699 @default.
• W2113244148 cites W2148029218 @default.
• W2113244148 cites W2157936339 @default.
• W2113244148 cites W2165915823 @default.
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• W2113244148 doi "https://doi.org/10.2478/v10042-009-0056-5" @default.
• W2113244148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20067897" @default.
• W2113244148 hasPublicationYear "2010" @default.
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