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• W2113244413 abstract "Ocimum basilicum L. (Lamiaceae) is a well-known perennial herb in Indian medicine used to treat various disorders like upper respiratory tract infections and wound healing. Primarily we investigated the anti-inflammatory activity of crude extracts of Ocimum basilicum using peripheral blood mononuclear cells (PBMC) of healthy individuals. Ocimum basilicum crude methanolic extract showed a good inhibitory effect on the proliferative response of PBMC in mitogenic lymphocyte proliferation assays. Furthermore, gene expression studies on lipopolysaccharide (LPS) induced production of proinflammatory cytokines like Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β) and IL-2 showed down regulation of the markers. It also suppressed the induction of inducible nitric oxide synthase (iNOS) and the subsequent production of nitric oxide (NO) in LPS-stimulated RAW 264.7 macrophages in a time-dependent manner. Our results showed that Ocimum basilicum crude methanolic extract inhibits the key proinflammatory cytokines and mediators, which accounts for its anti-inflammatory effect." @default.
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• W2113244413 date "2007-01-01" @default.
• W2113244413 modified "2023-10-05" @default.
• W2113244413 title "Potential Anti-inflammatory Properties of Crude Alcoholic Extract of Ocimum basilicum L. in Human Peripheral Blood Mononuclear Cells" @default.
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• W2113244413 doi "https://doi.org/10.1248/jhs.53.500" @default.
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