FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113245812> ?p ?o ?g. }

• W2113245812 endingPage "98" @default.
• W2113245812 startingPage "91" @default.
• W2113245812 abstract "We have investigated a new mechanism by which epidermal growth factor (EGF) increases intracellular Ca(2+) ([Ca(2+)](i)) in Rat-2 fibroblasts. EGF induced a transient increase of [Ca(2+)](i), and sustained Ca(2+) increase disappeared in the absence of extracellular Ca(2+). However, EGF had no effect on the formation of inositol phosphates. Expression of N17Rac or scrape-loading of C3 transferase blocked the elevation of [Ca(2+)](i) by EGF, but not by lysophosphatidic acid (LPA). EGF increased intracellular H(2)O(2), with a maximal increase at 5 min, which was blocked by catalase, scrape-loading of C3 transferase, or expression of N17Rac. H(2)O(2) scavengers, catalase and N-acetyl-L-cysteine, also blocked the Ca(2+) response to EGF, but not to LPA. In the presence of EGTA, preincubation with EGF completely inhibited subsequent Ca(2+) response to extracellular H(2)O(2) and vice versa. Incubation with EGF or phosphatidic acid abolished subsequent elevation of [Ca(2+)](i) by phosphatidic acid or EGF, respectively. Furthermore, preincubation with LPA inhibited the subsequent Ca(2+) response to EGF, but not vice versa. These results suggested that intracellular H(2)O(2) regulated by Rac and RhoA, but not inositol phosphates, was responsible for the EGF-stimulated elevation of [Ca(2+)](i). It was also suggested that EGF cross talked with LPA in the regulation of [Ca(2+)](i) by producing intracellular H(2)O(2)." @default.
• W2113245812 created "2016-06-24" @default.
• W2113245812 creator A5033853018 @default.
• W2113245812 creator A5034953122 @default.
• W2113245812 creator A5054672459 @default.
• W2113245812 creator A5056878388 @default.
• W2113245812 creator A5061300966 @default.
• W2113245812 creator A5077434713 @default.
• W2113245812 creator A5087032705 @default.
• W2113245812 date "2000-02-01" @default.
• W2113245812 modified "2023-09-28" @default.
• W2113245812 title "The essential role of H2O2 in the regulation of intracellular Ca2+ by epidermal growth factor in Rat-2 fibroblasts" @default.
• W2113245812 cites W1487679352 @default.
• W2113245812 cites W1495442004 @default.
• W2113245812 cites W1527715380 @default.
• W2113245812 cites W1542410585 @default.
• W2113245812 cites W1552398236 @default.
• W2113245812 cites W1580635581 @default.
• W2113245812 cites W1585236678 @default.
• W2113245812 cites W1669215771 @default.
• W2113245812 cites W1870773788 @default.
• W2113245812 cites W1969443667 @default.
• W2113245812 cites W1969670025 @default.
• W2113245812 cites W1972960760 @default.
• W2113245812 cites W1973901790 @default.
• W2113245812 cites W1978918867 @default.
• W2113245812 cites W2001322050 @default.
• W2113245812 cites W2016888262 @default.
• W2113245812 cites W2017100096 @default.
• W2113245812 cites W2020993672 @default.
• W2113245812 cites W2021165698 @default.
• W2113245812 cites W2023312698 @default.
• W2113245812 cites W2027810531 @default.
• W2113245812 cites W2048569323 @default.
• W2113245812 cites W2049380788 @default.
• W2113245812 cites W2056918775 @default.
• W2113245812 cites W2057163366 @default.
• W2113245812 cites W2072569792 @default.
• W2113245812 cites W2081629504 @default.
• W2113245812 cites W2088032374 @default.
• W2113245812 cites W2092491649 @default.
• W2113245812 cites W2104251051 @default.
• W2113245812 cites W2119780153 @default.
• W2113245812 cites W2149870206 @default.
• W2113245812 cites W2152311269 @default.
• W2113245812 cites W330009103 @default.
• W2113245812 doi "https://doi.org/10.1016/s0898-6568(99)00069-8" @default.
• W2113245812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10679577" @default.
• W2113245812 hasPublicationYear "2000" @default.
• W2113245812 type Work @default.
• W2113245812 sameAs 2113245812 @default.
• W2113245812 citedByCount "21" @default.
• W2113245812 countsByYear W21132458122012 @default.
• W2113245812 countsByYear W21132458122015 @default.
• W2113245812 countsByYear W21132458122016 @default.
• W2113245812 countsByYear W21132458122017 @default.
• W2113245812 crossrefType "journal-article" @default.
• W2113245812 hasAuthorship W2113245812A5033853018 @default.
• W2113245812 hasAuthorship W2113245812A5034953122 @default.
• W2113245812 hasAuthorship W2113245812A5054672459 @default.
• W2113245812 hasAuthorship W2113245812A5056878388 @default.
• W2113245812 hasAuthorship W2113245812A5061300966 @default.
• W2113245812 hasAuthorship W2113245812A5077434713 @default.
• W2113245812 hasAuthorship W2113245812A5087032705 @default.
• W2113245812 hasConcept C126322002 @default.
• W2113245812 hasConcept C134018914 @default.
• W2113245812 hasConcept C170493617 @default.
• W2113245812 hasConcept C178790620 @default.
• W2113245812 hasConcept C185592680 @default.
• W2113245812 hasConcept C2776362946 @default.
• W2113245812 hasConcept C2776661833 @default.
• W2113245812 hasConcept C2776909261 @default.
• W2113245812 hasConcept C2776989580 @default.
• W2113245812 hasConcept C2777427919 @default.
• W2113245812 hasConcept C2777658833 @default.
• W2113245812 hasConcept C2778918659 @default.
• W2113245812 hasConcept C28406088 @default.
• W2113245812 hasConcept C41625074 @default.
• W2113245812 hasConcept C519063684 @default.
• W2113245812 hasConcept C55493867 @default.
• W2113245812 hasConcept C71924100 @default.
• W2113245812 hasConcept C79879829 @default.
• W2113245812 hasConcept C86803240 @default.
• W2113245812 hasConceptScore W2113245812C126322002 @default.
• W2113245812 hasConceptScore W2113245812C134018914 @default.
• W2113245812 hasConceptScore W2113245812C170493617 @default.
• W2113245812 hasConceptScore W2113245812C178790620 @default.
• W2113245812 hasConceptScore W2113245812C185592680 @default.
• W2113245812 hasConceptScore W2113245812C2776362946 @default.
• W2113245812 hasConceptScore W2113245812C2776661833 @default.
• W2113245812 hasConceptScore W2113245812C2776909261 @default.
• W2113245812 hasConceptScore W2113245812C2776989580 @default.
• W2113245812 hasConceptScore W2113245812C2777427919 @default.
• W2113245812 hasConceptScore W2113245812C2777658833 @default.
• W2113245812 hasConceptScore W2113245812C2778918659 @default.
• W2113245812 hasConceptScore W2113245812C28406088 @default.
• W2113245812 hasConceptScore W2113245812C41625074 @default.
• W2113245812 hasConceptScore W2113245812C519063684 @default.

• next