Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113247498> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2113247498 endingPage "S5" @default.
- W2113247498 startingPage "S3" @default.
- W2113247498 abstract "Cigarette smoking is the leading cause for the initiation and development of cardiovascular disease (CVD). Oxidative stress and inflammatory responses play important roles in the pathophysiological processes of smoking-induced cardiac injury. (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea, which is made from Camellia sinensis leaves, has been reported to possess potent anti-oxidant property.This study aims to investigate whether the antioxidant EGCG could alleviate cigarette smoke medium (CSM)-induced inflammation in human AC16 cardiomyocytes in vitro.Human AC16 cardiomyocytes were pre-treated with EGCG, N-acetyl-L-cysteine (NAC), or specific inhibitors for 30 min before 4% CSM was added. Supernatant was collected for determination of interleukin (IL)-8 by ELISA and cells were collected for flow cytometry, biochemical assays and Western blot analysis.EGCG treatment significantly attenuated CSM-induced oxidative stress as evidenced by reducing intracellular and mitochondrial reactive oxygen species (ROS) generations and preventing antioxidant depletion. EGCG treatment reduced CSM-induced inflammatory chemokine interleukin (IL)-8 productions in the supernatant via the inhibition of ERK1/2, p38 MAPK and NF-κB pathways. EGCG treatment further inhibited CSM-induced cell apoptosis.Taken together, EGCG protected against CSM-induced inflammation and cell apoptosis by attenuating oxidative stress via inhibiting ERK1/2, p38 MAPK, and NF-κB activation in AC16 cardiomyocytes. These findings suggest that EGCG with its antioxidant, anti-inflammatory and anti-apoptotic properties may act as a promising cardioprotective agent against ROS-mediated cardiac injury." @default.
- W2113247498 created "2016-06-24" @default.
- W2113247498 creator A5051128396 @default.
- W2113247498 creator A5061764201 @default.
- W2113247498 date "2008-06-01" @default.
- W2113247498 modified "2023-10-14" @default.
- W2113247498 title "L’insuffisance cardiaque aiguë au cours de l’infarctus du myocarde" @default.
- W2113247498 cites W1975119386 @default.
- W2113247498 cites W1976855958 @default.
- W2113247498 cites W2001862663 @default.
- W2113247498 cites W2014254092 @default.
- W2113247498 cites W2023259170 @default.
- W2113247498 cites W2034185700 @default.
- W2113247498 cites W2040884428 @default.
- W2113247498 cites W2116514292 @default.
- W2113247498 cites W2124385783 @default.
- W2113247498 cites W2129656997 @default.
- W2113247498 cites W2142258305 @default.
- W2113247498 cites W2147615829 @default.
- W2113247498 cites W2154034857 @default.
- W2113247498 cites W2162875449 @default.
- W2113247498 doi "https://doi.org/10.1016/j.revmed.2008.03.025" @default.
- W2113247498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18467008" @default.
- W2113247498 hasPublicationYear "2008" @default.
- W2113247498 type Work @default.
- W2113247498 sameAs 2113247498 @default.
- W2113247498 citedByCount "1" @default.
- W2113247498 countsByYear W21132474982014 @default.
- W2113247498 crossrefType "journal-article" @default.
- W2113247498 hasAuthorship W2113247498A5051128396 @default.
- W2113247498 hasAuthorship W2113247498A5061764201 @default.
- W2113247498 hasConcept C185592680 @default.
- W2113247498 hasConcept C190283241 @default.
- W2113247498 hasConcept C203014093 @default.
- W2113247498 hasConcept C2776151105 @default.
- W2113247498 hasConcept C2776914184 @default.
- W2113247498 hasConcept C2778004101 @default.
- W2113247498 hasConcept C48349386 @default.
- W2113247498 hasConcept C51551487 @default.
- W2113247498 hasConcept C55493867 @default.
- W2113247498 hasConcept C57074206 @default.
- W2113247498 hasConcept C62478195 @default.
- W2113247498 hasConcept C71924100 @default.
- W2113247498 hasConcept C98274493 @default.
- W2113247498 hasConceptScore W2113247498C185592680 @default.
- W2113247498 hasConceptScore W2113247498C190283241 @default.
- W2113247498 hasConceptScore W2113247498C203014093 @default.
- W2113247498 hasConceptScore W2113247498C2776151105 @default.
- W2113247498 hasConceptScore W2113247498C2776914184 @default.
- W2113247498 hasConceptScore W2113247498C2778004101 @default.
- W2113247498 hasConceptScore W2113247498C48349386 @default.
- W2113247498 hasConceptScore W2113247498C51551487 @default.
- W2113247498 hasConceptScore W2113247498C55493867 @default.
- W2113247498 hasConceptScore W2113247498C57074206 @default.
- W2113247498 hasConceptScore W2113247498C62478195 @default.
- W2113247498 hasConceptScore W2113247498C71924100 @default.
- W2113247498 hasConceptScore W2113247498C98274493 @default.
- W2113247498 hasLocation W21132474981 @default.
- W2113247498 hasLocation W21132474982 @default.
- W2113247498 hasOpenAccess W2113247498 @default.
- W2113247498 hasPrimaryLocation W21132474981 @default.
- W2113247498 hasRelatedWork W1490540217 @default.
- W2113247498 hasRelatedWork W1983176022 @default.
- W2113247498 hasRelatedWork W2034667072 @default.
- W2113247498 hasRelatedWork W2313463101 @default.
- W2113247498 hasRelatedWork W2347577273 @default.
- W2113247498 hasRelatedWork W2368772701 @default.
- W2113247498 hasRelatedWork W2395941482 @default.
- W2113247498 hasRelatedWork W2903340838 @default.
- W2113247498 hasRelatedWork W3197540311 @default.
- W2113247498 hasRelatedWork W99063305 @default.
- W2113247498 hasVolume "29" @default.
- W2113247498 isParatext "false" @default.
- W2113247498 isRetracted "false" @default.
- W2113247498 magId "2113247498" @default.
- W2113247498 workType "article" @default.