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- W2113247654 endingPage "422" @default.
- W2113247654 startingPage "411" @default.
- W2113247654 abstract "Type 2 diabetes (T2D) is a complex, progressive disease with life-threatening complications and one of the most serious public-health problems worldwide. The two main mechanisms of T2D pathogenesis are pancreatic beta cell dysfunction and insulin resistance. It is now recognized that pancreatic beta cell dysfunction is a necessary factor for T2D development. Traditional therapies for controlling blood glucose are suboptimal as they fail to meet target goals for many patients. Glucagon-like peptide-1 receptor agonists (GLP1RA) and dipeptidyl peptidase-4 inhibitors (DPP4I) are an attractive class of therapy because they reduce blood glucose by targeting the incretin hormone system and, in particular, have the potential to positively affect pancreatic beta cell biology. This review outlines our current understanding of pancreatic beta cell incretin system dysfunction in T2D and summarizes recent evidence of the effect of incretin-based therapies on beta cell function and mass. Incretin-based therapies have shown strong evidence for beneficial effects on beta cell function and mass in animal studies. In humans, incretin-based therapies are effective glucose-lowering agents, but further study is still required to evaluate their long-term effects on beta cell function and safety as well as beta cell mass expansion." @default.
- W2113247654 created "2016-06-24" @default.
- W2113247654 creator A5010776667 @default.
- W2113247654 creator A5025413315 @default.
- W2113247654 creator A5043073448 @default.
- W2113247654 creator A5052379718 @default.
- W2113247654 date "2014-12-01" @default.
- W2113247654 modified "2023-09-25" @default.
- W2113247654 title "Incretin-based therapy and pancreatic beta cells" @default.
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