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- W2113248936 abstract "The present study was undertaken to partly characterize and compare the relative amounts of the different molecular forms of somatostatin in the major somatostatin-containing tissues and portal plasma of the rat. Immunoreactive somatostatin (IRS) was extracted from hypothalamus, cerebral cortex, neural retina, sciatic nerve, pancreas, stomach, duodenum, jejunum, ileum, colon, and portal venous plasma and fractionated on Sephadex G-50 columns equilibrated with 6 M urea. Three peaks with somatostatin-like immunoreactivity (SLI) were identified. Peak I had an apparent molecular weight of 14,000 daltons, (14K SLI), peak II coeluted with synthetic somatostatin-28 (3K SLI), and peak III coeluted with SRIF (1.6K SLI). The relative proportions of the three molecular forms were unchanged after treatment with 8 M guanidine hydrochloride and thioglycol and varied considerably from tissue to tissue. In the hypothalamus and cerebral cortex, approximately 70% of the IRS was present as 1.6K SLI, 25% as 3K SLI, and 5% as..." @default.
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- W2113248936 date "1981-12-01" @default.
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- W2113248936 title "Multiple Forms of Immunoreactive Somatostatin: Comparison of Distribution in Neural and Nonneural Tissues and Portal Plasma of the Rat*" @default.
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- W2113248936 doi "https://doi.org/10.1210/endo-109-6-1943" @default.
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