FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113254169> ?p ?o ?g. }

• W2113254169 endingPage "311" @default.
• W2113254169 startingPage "309" @default.
• W2113254169 abstract "Several members of the organic anion transporting polypeptide (OATP/Oatp) family of uptake transporters are expressed in the hepatocyte sinusoidal membrane in humans and preclinical species. The mouse liver specific Oatp is Oatp1b2, and the human homologs most closely related are OATP1B1 and 1B3. The substrate specificity of these transporters is broad, and the widely accepted view is that they play an important role in drug disposition. However, direct evidence that OATP/Oatps are important for drug disposition in vivo has been lacking thus far. In this issue of <i>Molecular Pharmacology</i>, Zaher et al. (p. 320), along with Lu et al. (Toxicol Sci103<b>:</b>35-45, 2008) , report on the characterization of mice with a targeted disruption of the organic anion transporting polypeptide Oatp1b2. The Oatp1b2(-/-) mice were viable and fertile and did not demonstrate obvious phenotypic abnormalities. Zaher et al. performed a pharmacokinetic analysis with the human OATP1B1 and -1B3 substrates rifampicin and pravastatin and demonstrated a reduced liver-to-plasma ratio for these drugs in knockout compared with control mice, providing strong evidence that Oatp1b2 played an important role in the disposition of these drugs. Lu et al. found that the Oatp1b2(-/-) mice were completely resistant to hepatoxicity induced by phalloidin and microcystin-LR. Taken together, these data illustrate that Oatp1b2(-/-) mice are an important new model to investigate the role of this transporter in drug disposition and hepatotoxicity." @default.
• W2113254169 created "2016-06-24" @default.
• W2113254169 creator A5064222916 @default.
• W2113254169 creator A5082048814 @default.
• W2113254169 date "2008-05-20" @default.
• W2113254169 modified "2023-09-27" @default.
• W2113254169 title "Role of the Murine Organic Anion-Transporting Polypeptide 1b2 (Oatp1b2) in Drug Disposition and Hepatotoxicity: Fig. 1." @default.
• W2113254169 cites W1977839873 @default.
• W2113254169 cites W1992237854 @default.
• W2113254169 cites W2015755153 @default.
• W2113254169 cites W2024317644 @default.
• W2113254169 cites W2048521506 @default.
• W2113254169 cites W2076385318 @default.
• W2113254169 cites W2081213990 @default.
• W2113254169 cites W2084553493 @default.
• W2113254169 cites W2087213057 @default.
• W2113254169 cites W2092910855 @default.
• W2113254169 cites W2099043638 @default.
• W2113254169 cites W2106535916 @default.
• W2113254169 cites W2115151001 @default.
• W2113254169 cites W2115562189 @default.
• W2113254169 cites W2115572195 @default.
• W2113254169 cites W2131138924 @default.
• W2113254169 cites W2131976213 @default.
• W2113254169 cites W2133282432 @default.
• W2113254169 cites W2139121124 @default.
• W2113254169 cites W97964894 @default.
• W2113254169 doi "https://doi.org/10.1124/mol.108.048991" @default.
• W2113254169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18492796" @default.
• W2113254169 hasPublicationYear "2008" @default.
• W2113254169 type Work @default.
• W2113254169 sameAs 2113254169 @default.
• W2113254169 citedByCount "36" @default.
• W2113254169 countsByYear W21132541692012 @default.
• W2113254169 countsByYear W21132541692013 @default.
• W2113254169 countsByYear W21132541692014 @default.
• W2113254169 countsByYear W21132541692015 @default.
• W2113254169 countsByYear W21132541692016 @default.
• W2113254169 countsByYear W21132541692017 @default.
• W2113254169 countsByYear W21132541692018 @default.
• W2113254169 countsByYear W21132541692020 @default.
• W2113254169 countsByYear W21132541692021 @default.
• W2113254169 countsByYear W21132541692022 @default.
• W2113254169 countsByYear W21132541692023 @default.
• W2113254169 crossrefType "journal-article" @default.
• W2113254169 hasAuthorship W2113254169A5064222916 @default.
• W2113254169 hasAuthorship W2113254169A5082048814 @default.
• W2113254169 hasConcept C104317684 @default.
• W2113254169 hasConcept C112705442 @default.
• W2113254169 hasConcept C123584848 @default.
• W2113254169 hasConcept C149011108 @default.
• W2113254169 hasConcept C15744967 @default.
• W2113254169 hasConcept C168785527 @default.
• W2113254169 hasConcept C170493617 @default.
• W2113254169 hasConcept C182704531 @default.
• W2113254169 hasConcept C185592680 @default.
• W2113254169 hasConcept C189613389 @default.
• W2113254169 hasConcept C207001950 @default.
• W2113254169 hasConcept C2776678969 @default.
• W2113254169 hasConcept C2780035454 @default.
• W2113254169 hasConcept C36201501 @default.
• W2113254169 hasConcept C38022665 @default.
• W2113254169 hasConcept C44312359 @default.
• W2113254169 hasConcept C54355233 @default.
• W2113254169 hasConcept C55493867 @default.
• W2113254169 hasConcept C77805123 @default.
• W2113254169 hasConcept C86803240 @default.
• W2113254169 hasConcept C98274493 @default.
• W2113254169 hasConceptScore W2113254169C104317684 @default.
• W2113254169 hasConceptScore W2113254169C112705442 @default.
• W2113254169 hasConceptScore W2113254169C123584848 @default.
• W2113254169 hasConceptScore W2113254169C149011108 @default.
• W2113254169 hasConceptScore W2113254169C15744967 @default.
• W2113254169 hasConceptScore W2113254169C168785527 @default.
• W2113254169 hasConceptScore W2113254169C170493617 @default.
• W2113254169 hasConceptScore W2113254169C182704531 @default.
• W2113254169 hasConceptScore W2113254169C185592680 @default.
• W2113254169 hasConceptScore W2113254169C189613389 @default.
• W2113254169 hasConceptScore W2113254169C207001950 @default.
• W2113254169 hasConceptScore W2113254169C2776678969 @default.
• W2113254169 hasConceptScore W2113254169C2780035454 @default.
• W2113254169 hasConceptScore W2113254169C36201501 @default.
• W2113254169 hasConceptScore W2113254169C38022665 @default.
• W2113254169 hasConceptScore W2113254169C44312359 @default.
• W2113254169 hasConceptScore W2113254169C54355233 @default.
• W2113254169 hasConceptScore W2113254169C55493867 @default.
• W2113254169 hasConceptScore W2113254169C77805123 @default.
• W2113254169 hasConceptScore W2113254169C86803240 @default.
• W2113254169 hasConceptScore W2113254169C98274493 @default.
• W2113254169 hasIssue "2" @default.
• W2113254169 hasLocation W21132541691 @default.
• W2113254169 hasLocation W21132541692 @default.
• W2113254169 hasOpenAccess W2113254169 @default.
• W2113254169 hasPrimaryLocation W21132541691 @default.
• W2113254169 hasRelatedWork W1596705130 @default.
• W2113254169 hasRelatedWork W1997040709 @default.
• W2113254169 hasRelatedWork W2098118571 @default.
• W2113254169 hasRelatedWork W2111016578 @default.

• next