FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113255992> ?p ?o ?g. }

• W2113255992 endingPage "19" @default.
• W2113255992 startingPage "9" @default.
• W2113255992 abstract "Constructs composed of cell wall mannan-derived moieties conjugated to immunogenic proteins could be promising agents for induction of protective anti-Candida immune responses.This report is focused on the cellular immune response differences induced by BSA-based conjugates bearing synthetic α-1,6-branched oligomannosides. For monitoring of the immune responses following active immunization we evaluated changes in the frequencies of T and B lymphocytes and their activation status in the blood and spleen. We compared the immunization-induced changes of co-stimulatory molecules CD80 and CD86 expression on blood neutrophils and Th1/Th2 polarization of the immune response based on IFN-γ, TNF-α (pro-Th1), IL-4, and IL-10 (pro-Th2) cytokines levels and induction of IL-17.The results pointed out a comparable effect of the conjugates on the modulation of T and B lymphocytes frequencies in blood and spleen. Both conjugates induced upregulation of CD25 surface antigen on CD4(+) T lymphocytes, independently on the structural differences of oligosaccharides. The differences in structure of oligomannoside antigens or conjugate constructs were reflected in the increase of co-stimulatory molecules CD80 and CD86 expression on neutrophils, and in induced cytokine response. M5-BSA conjugate induced only a slight increase in CD80 expression but a significant increase in IFN-γ, TNF-α, and IL-10. M6-BSA conjugate induced a significant increase of CD80 expression and increase of TNF-α, IL-4, and IL-10.Obtained data demonstrate the importance of cellular immune response analysis for investigation of immunomodulatory properties of oligomannoside-protein conjugates." @default.
• W2113255992 created "2016-06-24" @default.
• W2113255992 creator A5007094185 @default.
• W2113255992 creator A5014595517 @default.
• W2113255992 creator A5030234011 @default.
• W2113255992 creator A5039127618 @default.
• W2113255992 creator A5061137593 @default.
• W2113255992 creator A5067545717 @default.
• W2113255992 date "2015-02-01" @default.
• W2113255992 modified "2023-10-17" @default.
• W2113255992 title "Immune cell response to Candida cell wall mannan derived branched α-oligomannoside conjugates in mice" @default.
• W2113255992 cites W122749646 @default.
• W2113255992 cites W1499921224 @default.
• W2113255992 cites W1624894109 @default.
• W2113255992 cites W1954254123 @default.
• W2113255992 cites W1968155668 @default.
• W2113255992 cites W1973111584 @default.
• W2113255992 cites W1986586971 @default.
• W2113255992 cites W1993219448 @default.
• W2113255992 cites W1997351008 @default.
• W2113255992 cites W1999992455 @default.
• W2113255992 cites W2002656082 @default.
• W2113255992 cites W2002836781 @default.
• W2113255992 cites W2006862282 @default.
• W2113255992 cites W2012241435 @default.
• W2113255992 cites W2018337931 @default.
• W2113255992 cites W2022022413 @default.
• W2113255992 cites W2029713274 @default.
• W2113255992 cites W2034141629 @default.
• W2113255992 cites W2042894751 @default.
• W2113255992 cites W2071482126 @default.
• W2113255992 cites W2071499523 @default.
• W2113255992 cites W2085387269 @default.
• W2113255992 cites W2090928701 @default.
• W2113255992 cites W2112765785 @default.
• W2113255992 cites W2114158362 @default.
• W2113255992 cites W2119044988 @default.
• W2113255992 cites W2122262578 @default.
• W2113255992 cites W2135037409 @default.
• W2113255992 cites W2135079499 @default.
• W2113255992 cites W2138062851 @default.
• W2113255992 cites W2147207093 @default.
• W2113255992 cites W2152087265 @default.
• W2113255992 cites W2154525396 @default.
• W2113255992 cites W2156792116 @default.
• W2113255992 cites W2158200334 @default.
• W2113255992 cites W2161206900 @default.
• W2113255992 cites W2169772540 @default.
• W2113255992 cites W4236155910 @default.
• W2113255992 cites W7851764 @default.
• W2113255992 doi "https://doi.org/10.1016/j.jmii.2013.08.020" @default.
• W2113255992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24239417" @default.
• W2113255992 hasPublicationYear "2015" @default.
• W2113255992 type Work @default.
• W2113255992 sameAs 2113255992 @default.
• W2113255992 citedByCount "14" @default.
• W2113255992 countsByYear W21132559922015 @default.
• W2113255992 countsByYear W21132559922016 @default.
• W2113255992 countsByYear W21132559922017 @default.
• W2113255992 countsByYear W21132559922018 @default.
• W2113255992 countsByYear W21132559922020 @default.
• W2113255992 countsByYear W21132559922021 @default.
• W2113255992 countsByYear W21132559922023 @default.
• W2113255992 crossrefType "journal-article" @default.
• W2113255992 hasAuthorship W2113255992A5007094185 @default.
• W2113255992 hasAuthorship W2113255992A5014595517 @default.
• W2113255992 hasAuthorship W2113255992A5030234011 @default.
• W2113255992 hasAuthorship W2113255992A5039127618 @default.
• W2113255992 hasAuthorship W2113255992A5061137593 @default.
• W2113255992 hasAuthorship W2113255992A5067545717 @default.
• W2113255992 hasBestOaLocation W21132559921 @default.
• W2113255992 hasConcept C100817775 @default.
• W2113255992 hasConcept C147483822 @default.
• W2113255992 hasConcept C154317977 @default.
• W2113255992 hasConcept C17991360 @default.
• W2113255992 hasConcept C185592680 @default.
• W2113255992 hasConcept C202751555 @default.
• W2113255992 hasConcept C203014093 @default.
• W2113255992 hasConcept C2776090121 @default.
• W2113255992 hasConcept C2778297628 @default.
• W2113255992 hasConcept C2778690821 @default.
• W2113255992 hasConcept C2779719659 @default.
• W2113255992 hasConcept C2781101188 @default.
• W2113255992 hasConcept C39347974 @default.
• W2113255992 hasConcept C55493867 @default.
• W2113255992 hasConcept C86803240 @default.
• W2113255992 hasConcept C8891405 @default.
• W2113255992 hasConceptScore W2113255992C100817775 @default.
• W2113255992 hasConceptScore W2113255992C147483822 @default.
• W2113255992 hasConceptScore W2113255992C154317977 @default.
• W2113255992 hasConceptScore W2113255992C17991360 @default.
• W2113255992 hasConceptScore W2113255992C185592680 @default.
• W2113255992 hasConceptScore W2113255992C202751555 @default.
• W2113255992 hasConceptScore W2113255992C203014093 @default.
• W2113255992 hasConceptScore W2113255992C2776090121 @default.
• W2113255992 hasConceptScore W2113255992C2778297628 @default.
• W2113255992 hasConceptScore W2113255992C2778690821 @default.
• W2113255992 hasConceptScore W2113255992C2779719659 @default.

• next