FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113257072> ?p ?o ?g. }

• W2113257072 endingPage "6135" @default.
• W2113257072 startingPage "6126" @default.
• W2113257072 abstract "The transplacental passage of thyroid hormones (THs) from mother to fetus in humans has been deduced from observational clinical studies and is important for normal fetoplacental development. To investigate the transporters that regulate TH uptake by syncytiotrophoblast (the primary barrier to maternal-fetal exchange, which lies in direct contact with maternal blood), we isolated the microvillous plasma membrane (MVM) of human term syncytiotrophoblasts. We have demonstrated that MVM vesicles express plasma membrane TH transporter proteins, including system-L (L-type amino acid transporter 1 and CD98), monocarboxylate transporters (MCTs) 8 and 10, organic anion-transporting polypeptides 1A2 and 4A1. We provide the first definitive evidence that the human syncytiotrophoblast MVM is capable of rapid, saturable T(4) and T(3) uptake at similar rates and in a Na(+)-independent manner. These two major forms of THs could not significantly inhibit each others' uptake, suggesting that each is mediated by largely different transporters. No single transporter was noted to play a dominant role in either T(4) or T(3) uptake. Using combinations of transporter inhibitors that had an additive effect on TH uptake, we provide evidence that 67% of saturable T(4) uptake is facilitated by system-L and MCT10 with a minor role played by organic anion-transporting polypeptides, whereas 87% of saturable T(3) uptake is mediated by MCT8 and MCT10. Our data demonstrate that syncytiotrophoblast may control the quantity and forms of THs taken up by the human placenta. Thus, syncytiotrophoblast could be critical in regulating transplacental TH supply from the mother to the fetus." @default.
• W2113257072 created "2016-06-24" @default.
• W2113257072 creator A5001381782 @default.
• W2113257072 creator A5005574329 @default.
• W2113257072 creator A5013087727 @default.
• W2113257072 creator A5057139017 @default.
• W2113257072 creator A5066463861 @default.
• W2113257072 creator A5072658992 @default.
• W2113257072 creator A5083895544 @default.
• W2113257072 date "2012-12-01" @default.
• W2113257072 modified "2023-10-18" @default.
• W2113257072 title "Expression and Function of Thyroid Hormone Transporters in the Microvillous Plasma Membrane of Human Term Placental Syncytiotrophoblast" @default.
• W2113257072 cites W1512446190 @default.
• W2113257072 cites W1589270353 @default.
• W2113257072 cites W1809505051 @default.
• W2113257072 cites W1882050418 @default.
• W2113257072 cites W1962144006 @default.
• W2113257072 cites W1964349780 @default.
• W2113257072 cites W1977677577 @default.
• W2113257072 cites W1977680584 @default.
• W2113257072 cites W1980423554 @default.
• W2113257072 cites W1986520434 @default.
• W2113257072 cites W1990085978 @default.
• W2113257072 cites W2001693234 @default.
• W2113257072 cites W2007210421 @default.
• W2113257072 cites W2011748398 @default.
• W2113257072 cites W2015128371 @default.
• W2113257072 cites W2024033226 @default.
• W2113257072 cites W2025806450 @default.
• W2113257072 cites W2026819209 @default.
• W2113257072 cites W2027256085 @default.
• W2113257072 cites W2027742043 @default.
• W2113257072 cites W2031595392 @default.
• W2113257072 cites W2032219201 @default.
• W2113257072 cites W2042656992 @default.
• W2113257072 cites W2042663996 @default.
• W2113257072 cites W2064188091 @default.
• W2113257072 cites W2076684549 @default.
• W2113257072 cites W2077024560 @default.
• W2113257072 cites W2079666076 @default.
• W2113257072 cites W2085099685 @default.
• W2113257072 cites W2101896526 @default.
• W2113257072 cites W2102129489 @default.
• W2113257072 cites W2106456872 @default.
• W2113257072 cites W2108465352 @default.
• W2113257072 cites W2108671981 @default.
• W2113257072 cites W2118284156 @default.
• W2113257072 cites W2126602785 @default.
• W2113257072 cites W2126880712 @default.
• W2113257072 cites W2127859037 @default.
• W2113257072 cites W2138527530 @default.
• W2113257072 cites W2142504483 @default.
• W2113257072 cites W2158972275 @default.
• W2113257072 cites W2160428231 @default.
• W2113257072 cites W2160488497 @default.
• W2113257072 cites W2162886210 @default.
• W2113257072 cites W2329856164 @default.
• W2113257072 cites W2334882251 @default.
• W2113257072 cites W2416761522 @default.
• W2113257072 cites W938454077 @default.
• W2113257072 doi "https://doi.org/10.1210/en.2012-1753" @default.
• W2113257072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4192285" @default.
• W2113257072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23087173" @default.
• W2113257072 hasPublicationYear "2012" @default.
• W2113257072 type Work @default.
• W2113257072 sameAs 2113257072 @default.
• W2113257072 citedByCount "24" @default.
• W2113257072 countsByYear W21132570722013 @default.
• W2113257072 countsByYear W21132570722014 @default.
• W2113257072 countsByYear W21132570722015 @default.
• W2113257072 countsByYear W21132570722016 @default.
• W2113257072 countsByYear W21132570722017 @default.
• W2113257072 countsByYear W21132570722018 @default.
• W2113257072 countsByYear W21132570722019 @default.
• W2113257072 countsByYear W21132570722020 @default.
• W2113257072 countsByYear W21132570722022 @default.
• W2113257072 countsByYear W21132570722023 @default.
• W2113257072 crossrefType "journal-article" @default.
• W2113257072 hasAuthorship W2113257072A5001381782 @default.
• W2113257072 hasAuthorship W2113257072A5005574329 @default.
• W2113257072 hasAuthorship W2113257072A5013087727 @default.
• W2113257072 hasAuthorship W2113257072A5057139017 @default.
• W2113257072 hasAuthorship W2113257072A5066463861 @default.
• W2113257072 hasAuthorship W2113257072A5072658992 @default.
• W2113257072 hasAuthorship W2113257072A5083895544 @default.
• W2113257072 hasBestOaLocation W21132570721 @default.
• W2113257072 hasConcept C104317684 @default.
• W2113257072 hasConcept C126322002 @default.
• W2113257072 hasConcept C134018914 @default.
• W2113257072 hasConcept C149011108 @default.
• W2113257072 hasConcept C168785527 @default.
• W2113257072 hasConcept C172680121 @default.
• W2113257072 hasConcept C185592680 @default.
• W2113257072 hasConcept C2776953305 @default.
• W2113257072 hasConcept C2779234561 @default.
• W2113257072 hasConcept C2779315647 @default.
• W2113257072 hasConcept C2779906218 @default.
• W2113257072 hasConcept C2780899479 @default.

• next