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• W2113258044 abstract "The antihyperglycemic and antinociceptive potentials of methanolic extract of Colocasia esculenta (L.) Schott (Araceae) stems were studied, respectively, by oral glucose tolerance tests and acetic acid-induced gastric pain constriction model in Swiss albino mice. In oral glucose tolerance tests conducted with glucose-loaded mice, the extract when administered at doses of 50, 100, 200 and 400 mg per kg body weight in mice resulted in inhibitions of rise in blood glucose concentrations, respectively, by 20.7, 24.7, 33.0 and 37.5%. The fall in blood glucose concentrations were both dose-dependent and statistically significant. A standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, resulted in a drop of blood glucose level by 46.1%. The results suggest that the extract possess quite good antihyperglycemic activity and the stems could be used for further investigations towards isolation of possibly potent antihyperglycemic component(s). Antinociceptive activity of the extract was studied by induction of gastric pain in mice through intraperitoneal injection of acetic acid, which resulted in abdominal constrictions. The extract, when administered at the afore-mentioned four doses caused dose-dependent and statistically significant inhibitions in the number of abdominal constrictions. The percent inhibitions at doses of 50, 100, 200 and 400 mg extract per kg body weight were, respectively, 50.0, 53.3, 56.7, and 63.3. By comparison, a standard antinociceptive drug, aspirin, when administered at doses of 200 and 400 mg per kg body weight reduced the number of abdominal constrictions by 36.7 and 56.7%, respectively. The results suggest that the extract is more potent than aspirin in its antinociceptive potential and could be used for alleviation of pain. Studies are ongoing for isolation and identification of the responsible antinociceptive component(s) from stems." @default.
• W2113258044 created "2016-06-24" @default.
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• W2113258044 date "2013-01-01" @default.
• W2113258044 modified "2023-09-24" @default.
• W2113258044 title "Antihyperglycemic and antinociceptive activities of methanolic extract of Colocasia esculenta (L.) Schott stems: a preliminary study" @default.
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