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- W2113259183 abstract "Electron mnicroscopic studies of adenovirus preparations hla-ve revealed tlle presence of smnall virus-like partieles approximately 22 mn, in diameter in a runumber of hum-an and simiarn adenovirus types.' Some workers have irlterpreted these particles as being adenovirus subunits,4e while others' 1 have indicated that they represent a contaminating virus. Our early studies' suggested that lthe 22-m,u particles were viruses which replicated poorly, if at all, in human cells in the absence of adenovirus replication. Atchison et al.2 also presented evidence that the small particles were infectious, that they were defective, and that they were immunologically distinct from any knowii adenovirus antigen. They tentatively referred to this virus as adeno-associated virus (AAV) and we shall continue to use this name. The purpose of the present report is to describe some of the physical, biological, aind immunological characteristics of the small particles found in various adenovirus preparations with further evidenice that they are defective viruses and not adenovirus subunits." @default.
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- W2113259183 date "1966-06-01" @default.
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- W2113259183 title "Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristics." @default.
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- W2113259183 doi "https://doi.org/10.1073/pnas.55.6.1467" @default.
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