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• W2113267995 abstract "•Recent advances have facilitated the study of neural cis-regulatory elements. •This new work is reshaping our understanding of transcriptional regulatory networks. •Brain-specific transcriptional regulatory networks are altered in evolution and disease. Transcriptional mechanisms mediated by the binding of transcription factors (TFs) to cis-acting regulatory elements (CREs) in DNA play crucial roles in directing gene expression. While TFs have been extensively studied, less effort has gone towards the identification and functional characterization of CREs and associated epigenetic modulation. However, owing to methodological and analytical advances, more comprehensive studies of regulatory elements and mechanisms are now possible. We summarize recent progress in integrative analyses of these regulatory components in the development of the cerebral neocortex, the part of the brain involved in cognition and complex behavior. These studies are uncovering not only the underlying transcriptional regulatory networks, but also how these networks are altered across species and in neurological and psychiatric disorders. Transcriptional mechanisms mediated by the binding of transcription factors (TFs) to cis-acting regulatory elements (CREs) in DNA play crucial roles in directing gene expression. While TFs have been extensively studied, less effort has gone towards the identification and functional characterization of CREs and associated epigenetic modulation. However, owing to methodological and analytical advances, more comprehensive studies of regulatory elements and mechanisms are now possible. We summarize recent progress in integrative analyses of these regulatory components in the development of the cerebral neocortex, the part of the brain involved in cognition and complex behavior. These studies are uncovering not only the underlying transcriptional regulatory networks, but also how these networks are altered across species and in neurological and psychiatric disorders." @default.
• W2113267995 created "2016-06-24" @default.
• W2113267995 creator A5026436089 @default.
• W2113267995 creator A5082820156 @default.
• W2113267995 creator A5084408069 @default.
• W2113267995 date "2015-02-01" @default.
• W2113267995 modified "2023-10-18" @default.
• W2113267995 title "From trans to cis: transcriptional regulatory networks in neocortical development" @default.
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