Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113272675> ?p ?o ?g. }
- W2113272675 endingPage "517" @default.
- W2113272675 startingPage "513" @default.
- W2113272675 abstract "Preclinical Research Recent studies suggest that the mammalian genome alone cannot completely explain many physiological and pathophysiological phenomena including variability in phenotypes, drug responses, discordance between monozygotic twins for the same trait or disorder, and disease susceptibility of an individual. The missing link could be epigenetic modifications of genome such as DNA methylation, numerous posttranslational modifications of histone proteins and regulation of expression of microRNAs. Epigenetic modifications are well known and are involved in normal mammalian development. They are modulated globally and in a gene-specific manner by environmental factors including nutrition, hormones, toxins, and drugs. Age also plays an important role in gene–environmental interactions. Epigenomic pathways are essential for normal cellular functions with abnormalities in their programming leading to complex disorders including psychiatric diseases. Epigenetic factors can thus serve as molecular markers to predict the responsiveness of diseases to therapy. Further knowledge of epigenomic changes and identification of factors that mediate alterations in the epigenome may lead to new drug targets and therapies. In this overview the importance of epigenomics in drug development and therapies has been highlighted." @default.
- W2113272675 created "2016-06-24" @default.
- W2113272675 creator A5039096233 @default.
- W2113272675 date "2012-10-18" @default.
- W2113272675 modified "2023-09-24" @default.
- W2113272675 title "Role of Epigenomics in Drug Discovery and Therapies" @default.
- W2113272675 cites W127888533 @default.
- W2113272675 cites W1516818607 @default.
- W2113272675 cites W189857981 @default.
- W2113272675 cites W1966581820 @default.
- W2113272675 cites W1968601671 @default.
- W2113272675 cites W1969250251 @default.
- W2113272675 cites W1969879564 @default.
- W2113272675 cites W1982012849 @default.
- W2113272675 cites W1991014720 @default.
- W2113272675 cites W1993431726 @default.
- W2113272675 cites W2000859128 @default.
- W2113272675 cites W2007769219 @default.
- W2113272675 cites W2010347242 @default.
- W2113272675 cites W2020089910 @default.
- W2113272675 cites W2020246476 @default.
- W2113272675 cites W2024914385 @default.
- W2113272675 cites W2027399998 @default.
- W2113272675 cites W2034456152 @default.
- W2113272675 cites W2034667463 @default.
- W2113272675 cites W2034889832 @default.
- W2113272675 cites W2049280919 @default.
- W2113272675 cites W2054382585 @default.
- W2113272675 cites W2058261392 @default.
- W2113272675 cites W2061846743 @default.
- W2113272675 cites W2062366015 @default.
- W2113272675 cites W2074786141 @default.
- W2113272675 cites W2087204337 @default.
- W2113272675 cites W2090723511 @default.
- W2113272675 cites W2094172340 @default.
- W2113272675 cites W2094388721 @default.
- W2113272675 cites W2108167035 @default.
- W2113272675 cites W2108664872 @default.
- W2113272675 cites W2108735831 @default.
- W2113272675 cites W2114178217 @default.
- W2113272675 cites W2116536643 @default.
- W2113272675 cites W2117996813 @default.
- W2113272675 cites W2121074897 @default.
- W2113272675 cites W2122230573 @default.
- W2113272675 cites W2125916700 @default.
- W2113272675 cites W2130239724 @default.
- W2113272675 cites W2132084412 @default.
- W2113272675 cites W2134555277 @default.
- W2113272675 cites W2135812015 @default.
- W2113272675 cites W2137179118 @default.
- W2113272675 cites W2141792938 @default.
- W2113272675 cites W2144170022 @default.
- W2113272675 cites W2148745887 @default.
- W2113272675 cites W2149559991 @default.
- W2113272675 cites W2154162926 @default.
- W2113272675 cites W2161735414 @default.
- W2113272675 cites W2161951518 @default.
- W2113272675 cites W2169193886 @default.
- W2113272675 cites W2400806726 @default.
- W2113272675 cites W41542367 @default.
- W2113272675 cites W90661041 @default.
- W2113272675 doi "https://doi.org/10.1002/ddr.21044" @default.
- W2113272675 hasPublicationYear "2012" @default.
- W2113272675 type Work @default.
- W2113272675 sameAs 2113272675 @default.
- W2113272675 citedByCount "5" @default.
- W2113272675 countsByYear W21132726752013 @default.
- W2113272675 countsByYear W21132726752014 @default.
- W2113272675 countsByYear W21132726752017 @default.
- W2113272675 countsByYear W21132726752022 @default.
- W2113272675 countsByYear W21132726752023 @default.
- W2113272675 crossrefType "journal-article" @default.
- W2113272675 hasAuthorship W2113272675A5039096233 @default.
- W2113272675 hasConcept C104317684 @default.
- W2113272675 hasConcept C117717151 @default.
- W2113272675 hasConcept C121912465 @default.
- W2113272675 hasConcept C126322002 @default.
- W2113272675 hasConcept C150194340 @default.
- W2113272675 hasConcept C190727270 @default.
- W2113272675 hasConcept C2779134260 @default.
- W2113272675 hasConcept C2780035454 @default.
- W2113272675 hasConcept C41091548 @default.
- W2113272675 hasConcept C54355233 @default.
- W2113272675 hasConcept C60644358 @default.
- W2113272675 hasConcept C64903051 @default.
- W2113272675 hasConcept C64927066 @default.
- W2113272675 hasConcept C70721500 @default.
- W2113272675 hasConcept C71924100 @default.
- W2113272675 hasConcept C74187038 @default.
- W2113272675 hasConcept C86803240 @default.
- W2113272675 hasConcept C98274493 @default.
- W2113272675 hasConceptScore W2113272675C104317684 @default.
- W2113272675 hasConceptScore W2113272675C117717151 @default.
- W2113272675 hasConceptScore W2113272675C121912465 @default.
- W2113272675 hasConceptScore W2113272675C126322002 @default.
- W2113272675 hasConceptScore W2113272675C150194340 @default.
- W2113272675 hasConceptScore W2113272675C190727270 @default.
- W2113272675 hasConceptScore W2113272675C2779134260 @default.