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• W2113282073 abstract "Minor histocompatibility antigens are MHC-bound peptides and contribute to the generation of allo-responses after allogeneic transplantation. H60 is a dominant minor H antigen that induces a strong CD8 T-cell response in MHC-matched allogeneic transplantation settings. Here, we report establishment of a TCR transgenic mouse line named J15, wherein T cells express TCRs specific for H60 in complex with H-2K(b), and different fates of the thymocytes expressing J15 TCRs in various thymic antigenic environments. Thymocytes expressing the J15 TCRs were positively selected and differentiated into CD8(+) single positive (SP) cells in the thymus of C57BL/6 mice, wherein the cognate antigen H60 is not expressed. However, thymocytes were negatively selected in thymus tissue where H60 was transgenically expressed under the control of the actin promoter, with double-positive stages of cells being deleted. Despite the ability of the H60H peptide (LTFHYRNL) variant to induce cytotoxic activity from H60-specific CTL lines at ~50% of the activity induced by normal H60 peptides (LTFNYRNL), J15-expressing thymocytes were positively selected in the thymus where the variant H60H was transgenically expressed. These results demonstrate that a single amino-acid change in the H60 epitope peptide influences the fate of thymocytes expressing the cognate TCR." @default.
• W2113282073 created "2016-06-24" @default.
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• W2113282073 date "2015-01-01" @default.
• W2113282073 modified "2023-09-27" @default.
• W2113282073 title "Selection of Thymocytes Expressing Transgenic TCR Specific for a Minor Histocompatibility Antigen, H60" @default.
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• W2113282073 doi "https://doi.org/10.4110/in.2015.15.5.222" @default.
• W2113282073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4637343" @default.
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