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- W2113283798 abstract "An efficient method for the C3-glucuronidation of bile acids is developed under flow conditions. A modular mesoreactor assisted flow set-up was combined with statistical design of experiments to speed up the optimization of the Koenigs–Knorr reaction in terms of yield, regioselectivity, costs, as well as technical and practical standpoints. Using the optimal conditions, selective glucuronidation of naturally occurring bile acids was successfully achieved offering a new, valuable route to C3-glucuronidated bile acids useful for biological, diagnostic and PK/ADMET investigations." @default.
- W2113283798 created "2016-06-24" @default.
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- W2113283798 date "2014-09-26" @default.
- W2113283798 modified "2023-10-17" @default.
- W2113283798 title "Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization" @default.
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- W2113283798 doi "https://doi.org/10.1039/c4ob01911c" @default.
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