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• W2113295005 abstract "Significance: Radiation therapy is widely used for treatment of prostate cancer. Radiation can directly damage biologically important molecules; however, most effects of radiation-mediated cell killing are derived from the generated free radicals that alter cellular redox status. Multiple proinflammatory mediators can also influence redox status in irradiated cells and the surrounding microenvironment, thereby affecting prostate cancer progression and radiotherapy efficiency. Recent Advances: Ionizing radiation (IR)–generated oxidative stress can regulate and be regulated by the production of proinflammatory mediators. Depending on the type and stage of the prostate cancer cells, these proinflammatory mediators may lead to different biological consequences ranging from cell death to development of radioresistance. Critical Issues: Tumors are heterogeneous and dynamic communication occurs between stromal and prostate cancer cells, and complicated redox-regulated mechanisms exist in the tumor microenvironment. Thus, antioxidant and anti-inflammatory strategies should be carefully evaluated for each patient at different stages of the disease to maximize therapeutic benefits while minimizing unintended side effects. Future Directions: Compared with normal cells, tumor cells are usually under higher oxidative stress and secrete more proinflammatory mediators. Thus, redox status is often less adaptive in tumor cells than in their normal counterparts. This difference can be exploited in a search for new cancer therapeutics and treatment regimes that selectively activate cell death pathways in tumor cells with minimal unintended consequences in terms of chemo- and radio-resistance in tumor cells and toxicity in normal tissues. Antioxid. Redox Signal. 20, 1481–1500." @default.
• W2113295005 created "2016-06-24" @default.
• W2113295005 creator A5005401059 @default.
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• W2113295005 creator A5074581426 @default.
• W2113295005 date "2014-03-20" @default.
• W2113295005 modified "2023-10-01" @default.
• W2113295005 title "Redox-Mediated and Ionizing-Radiation-Induced Inflammatory Mediators in Prostate Cancer Development and Treatment" @default.
• W2113295005 cites W1548640328 @default.
• W2113295005 cites W1602943807 @default.
• W2113295005 cites W1828456061 @default.
• W2113295005 cites W1897551156 @default.
• W2113295005 cites W1923746164 @default.
• W2113295005 cites W1964037605 @default.
• W2113295005 cites W1964066987 @default.
• W2113295005 cites W1965037168 @default.
• W2113295005 cites W1966010244 @default.
• W2113295005 cites W1966223430 @default.
• W2113295005 cites W1969594138 @default.
• W2113295005 cites W1970195787 @default.
• W2113295005 cites W1971514924 @default.
• W2113295005 cites W1972572879 @default.
• W2113295005 cites W1972779889 @default.
• W2113295005 cites W1973515006 @default.
• W2113295005 cites W1976148924 @default.
• W2113295005 cites W1976619282 @default.
• W2113295005 cites W1977930150 @default.
• W2113295005 cites W1978420586 @default.
• W2113295005 cites W1979898371 @default.
• W2113295005 cites W1980258358 @default.
• W2113295005 cites W1982317600 @default.
• W2113295005 cites W1983113716 @default.
• W2113295005 cites W1983760621 @default.
• W2113295005 cites W1983835791 @default.
• W2113295005 cites W1984162437 @default.
• W2113295005 cites W1987073910 @default.
• W2113295005 cites W1988053280 @default.
• W2113295005 cites W1989102414 @default.
• W2113295005 cites W1990044336 @default.
• W2113295005 cites W1992837814 @default.
• W2113295005 cites W1995194065 @default.
• W2113295005 cites W1997238548 @default.
• W2113295005 cites W1997596656 @default.
• W2113295005 cites W1998696969 @default.
• W2113295005 cites W1999111479 @default.
• W2113295005 cites W2000097339 @default.
• W2113295005 cites W2000792691 @default.
• W2113295005 cites W2004018529 @default.
• W2113295005 cites W2004785214 @default.
• W2113295005 cites W2004859816 @default.
• W2113295005 cites W2005472560 @default.
• W2113295005 cites W2007278160 @default.
• W2113295005 cites W2009588836 @default.
• W2113295005 cites W2011006339 @default.
• W2113295005 cites W2011823212 @default.
• W2113295005 cites W2012033459 @default.
• W2113295005 cites W2013662603 @default.
• W2113295005 cites W2014098577 @default.
• W2113295005 cites W2014433188 @default.
• W2113295005 cites W2015843104 @default.
• W2113295005 cites W2017119868 @default.
• W2113295005 cites W2017727606 @default.
• W2113295005 cites W2025199554 @default.
• W2113295005 cites W2026297232 @default.
• W2113295005 cites W2026407880 @default.
• W2113295005 cites W2027253055 @default.
• W2113295005 cites W2027279302 @default.
• W2113295005 cites W2027589906 @default.
• W2113295005 cites W2030185151 @default.
• W2113295005 cites W2030971688 @default.
• W2113295005 cites W2032180256 @default.
• W2113295005 cites W2032431432 @default.
• W2113295005 cites W2033704934 @default.
• W2113295005 cites W2034191007 @default.
• W2113295005 cites W2037434205 @default.
• W2113295005 cites W2038259382 @default.
• W2113295005 cites W2039137468 @default.
• W2113295005 cites W2039428188 @default.
• W2113295005 cites W2040834391 @default.
• W2113295005 cites W2041193073 @default.
• W2113295005 cites W2041353769 @default.
• W2113295005 cites W2043276068 @default.
• W2113295005 cites W2043540557 @default.
• W2113295005 cites W2044155146 @default.
• W2113295005 cites W2045135900 @default.
• W2113295005 cites W2045457909 @default.
• W2113295005 cites W2048467313 @default.
• W2113295005 cites W2048824272 @default.
• W2113295005 cites W2049048127 @default.
• W2113295005 cites W2049860203 @default.
• W2113295005 cites W2050230453 @default.
• W2113295005 cites W2050517416 @default.
• W2113295005 cites W2051782670 @default.
• W2113295005 cites W2053481165 @default.
• W2113295005 cites W2054529396 @default.
• W2113295005 cites W2054801123 @default.

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