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• W2113296099 abstract "ABSTRACT RpoE2 is an extracytoplasmic function (ECF) sigma factor involved in the general stress response of Sinorhizobium meliloti , the nitrogen-fixing symbiont of the legume plant alfalfa. RpoE2 orthologues are widely found among alphaproteobacteria, where they play various roles in stress resistance and/or host colonization. In this paper, we report a genetic and biochemical investigation of the mechanisms of signal transduction leading to S. meliloti RpoE2 activation in response to stress. We showed that RpoE2 activity is negatively controlled by two paralogous anti-sigma factors, RsiA1 (SMc01505) and RsiA2 (SMc04884), and that RpoE2 activation by stress requires two redundant paralogous PhyR-type response regulators, RsiB1 (SMc01504) and RsiB2 (SMc00794). RsiB1 and RsiB2 do not act at the level of rpoE2 transcription but instead interact with the anti-sigma factors, and we therefore propose that they act as anti-anti-sigma factors to relieve RpoE2 inhibition in response to stress. This model closely resembles a recently proposed model of activation of RpoE2-like sigma factors in Methylobacterium extorquens and Bradyrhizobium japonicum , but the existence of two pairs of anti- and anti-anti-sigma factors in S. meliloti adds an unexpected level of complexity, which may allow the regulatory system to integrate multiple stimuli." @default.
• W2113296099 created "2016-06-24" @default.
• W2113296099 creator A5033696182 @default.
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• W2113296099 date "2010-04-15" @default.
• W2113296099 modified "2023-09-26" @default.
• W2113296099 title "Dual Control of <i>Sinorhizobium meliloti</i> RpoE2 Sigma Factor Activity by Two PhyR-Type Two-Component Response Regulators" @default.
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• W2113296099 doi "https://doi.org/10.1128/jb.01666-09" @default.
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