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- W2113296988 endingPage "366" @default.
- W2113296988 startingPage "347" @default.
- W2113296988 abstract "Natural products are important sources of pharmaceuticals, in part owing to their diverse biological activities. Enzymes from natural product biosynthetic pathways have become attractive candidates as biocatalysts for modifying the structures and bioactivities of these complex compounds. Numerous enzymes have been harvested to generate innovative scaffolds, large-scale synthesis of chiral building blocks, and semisynthesis of medicinally relevant natural product derivatives. This review discusses recent examples from three areas: (a) polyketide catalytic domain engineering geared toward synthesis of new polyketides, (b) engineering of tailoring enzymes (other than oxidative enzymes) as biocatalysts, and (c) in vitro total synthesis of natural products using purified enzyme components. With the availability of exponentially increasing genomic information and new genome mining tools, many new and powerful biocatalysts tailored for pharmaceutical synthesis will likely emerge from secondary metabolism." @default.
- W2113296988 created "2016-06-24" @default.
- W2113296988 creator A5014282065 @default.
- W2113296988 creator A5086448413 @default.
- W2113296988 date "2014-06-07" @default.
- W2113296988 modified "2023-10-17" @default.
- W2113296988 title "Biocatalysts for Natural Product Biosynthesis" @default.
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