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- W2113299423 abstract "Multifunctional polymers with defined structure and biocompatibility are critical to the development of drug delivery systems and bioconjugates. In this article, the synthesis, in vitro blood compatibility, cell viability, in vivo circulation, biodistribution, and clearance of hybrid copolymers based on linear and branched polyglycerol are reported. Hybrid polyglycerols ( ≈ 100 kDa) are synthesized with different compositions (15–80 mol% linear polyglycerol). Relatively small hydrodynamic size and radius of gyration of the hybrid polyglycerols suggest that they are highly compact functional nanostructures. The hybrid polyglycerols show excellent blood compatibility as determined by measuring their effects on blood coagulation, red blood cell aggregation, hemolysis, platelet, and complement activation. The cell viability in presence of hybrid polyglycerols is excellent up to 10 mg mL −1 concentration and is similar to both dextran and polyvinyl alcohol. Furthermore, tritium labeled hybrid polyglycerol shows long blood circulation ( t 1/2β = 34 h) with minimal organ accumulation in mice. Multifunctionality, compact nature, biocompatibility, and the long blood circulation make these polymers attractive for the development of bioconjugates and drug delivery systems." @default.
- W2113299423 created "2016-06-24" @default.
- W2113299423 creator A5001822496 @default.
- W2113299423 creator A5009893358 @default.
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- W2113299423 date "2014-07-11" @default.
- W2113299423 modified "2023-10-06" @default.
- W2113299423 title "Hybrid Polyglycerols with Long Blood Circulation: Synthesis, Biocompatibility, and Biodistribution" @default.
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- W2113299423 doi "https://doi.org/10.1002/mabi.201400152" @default.
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- W2113299423 hasPublicationYear "2014" @default.
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