FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113303013> ?p ?o ?g. }

• W2113303013 endingPage "2288" @default.
• W2113303013 startingPage "2276" @default.
• W2113303013 abstract "Although transcriptomic profiling has become the standard approach for exploring molecular differences in the primate brain, very little is known about how the expression levels of gene transcripts relate to downstream protein abundance. Moreover, it is unknown whether the relationship changes depending on the brain region or species under investigation. We performed high-throughput transcriptomic (RNA-Seq) and proteomic (liquid chromatography coupled with tandem mass spectrometry) analyses on two regions of the human and chimpanzee brain: The anterior cingulate cortex and caudate nucleus. In both brain regions, we found a lower correlation between mRNA and protein expression levels in humans and chimpanzees than has been reported for other tissues and cell types, suggesting that the brain may engage extensive tissue-specific regulation affecting protein abundance. In both species, only a few categories of biological function exhibited strong correlations between mRNA and protein expression levels. These categories included oxidative metabolism and protein synthesis and modification, indicating that the expression levels of mRNA transcripts supporting these biological functions are more predictive of protein expression compared with other functional categories. More generally, however, the two measures of molecular expression provided strikingly divergent perspectives into differential expression between human and chimpanzee brains: mRNA comparisons revealed significant differences in neuronal communication, ion transport, and regulatory processes, whereas protein comparisons indicated differences in perception and cognition, metabolic processes, and organization of the cytoskeleton. Our results highlight the importance of examining protein expression in evolutionary analyses and call for a more thorough understanding of tissue-specific protein expression levels." @default.
• W2113303013 created "2016-06-24" @default.
• W2113303013 creator A5031343306 @default.
• W2113303013 creator A5038805652 @default.
• W2113303013 creator A5054443109 @default.
• W2113303013 creator A5060687805 @default.
• W2113303013 creator A5063649186 @default.
• W2113303013 creator A5073037534 @default.
• W2113303013 creator A5080903509 @default.
• W2113303013 creator A5081032810 @default.
• W2113303013 creator A5083591763 @default.
• W2113303013 date "2015-07-10" @default.
• W2113303013 modified "2023-09-28" @default.
• W2113303013 title "Evolutionary Divergence of Gene and Protein Expression in the Brains of Humans and Chimpanzees" @default.
• W2113303013 cites W1689369637 @default.
• W2113303013 cites W1968164444 @default.
• W2113303013 cites W1972673599 @default.
• W2113303013 cites W1978083828 @default.
• W2113303013 cites W1979369962 @default.
• W2113303013 cites W1981661721 @default.
• W2113303013 cites W1989635088 @default.
• W2113303013 cites W1998325961 @default.
• W2113303013 cites W2007829231 @default.
• W2113303013 cites W2017019597 @default.
• W2113303013 cites W2026482820 @default.
• W2113303013 cites W2034299131 @default.
• W2113303013 cites W2036287649 @default.
• W2113303013 cites W2044286001 @default.
• W2113303013 cites W2044621597 @default.
• W2113303013 cites W2047847592 @default.
• W2113303013 cites W2052801529 @default.
• W2113303013 cites W2055655674 @default.
• W2113303013 cites W2056710301 @default.
• W2113303013 cites W2064274168 @default.
• W2113303013 cites W2069715270 @default.
• W2113303013 cites W2071466475 @default.
• W2113303013 cites W2073109785 @default.
• W2113303013 cites W2074871118 @default.
• W2113303013 cites W2076350171 @default.
• W2113303013 cites W2081837126 @default.
• W2113303013 cites W2086233060 @default.
• W2113303013 cites W2088390270 @default.
• W2113303013 cites W2088470456 @default.
• W2113303013 cites W2095805667 @default.
• W2113303013 cites W2097065948 @default.
• W2113303013 cites W2098039318 @default.
• W2113303013 cites W2102289725 @default.
• W2113303013 cites W2103017472 @default.
• W2113303013 cites W2105300968 @default.
• W2113303013 cites W2105507567 @default.
• W2113303013 cites W2105846417 @default.
• W2113303013 cites W2106329292 @default.
• W2113303013 cites W2114104545 @default.
• W2113303013 cites W2115847425 @default.
• W2113303013 cites W2122884875 @default.
• W2113303013 cites W2124659766 @default.
• W2113303013 cites W2125926103 @default.
• W2113303013 cites W2128551987 @default.
• W2113303013 cites W2128969076 @default.
• W2113303013 cites W2133147430 @default.
• W2113303013 cites W2133863540 @default.
• W2113303013 cites W2137314605 @default.
• W2113303013 cites W2141160550 @default.
• W2113303013 cites W2147881874 @default.
• W2113303013 cites W2151820055 @default.
• W2113303013 doi "https://doi.org/10.1093/gbe/evv132" @default.
• W2113303013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4558850" @default.
• W2113303013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26163674" @default.
• W2113303013 hasPublicationYear "2015" @default.
• W2113303013 type Work @default.
• W2113303013 sameAs 2113303013 @default.
• W2113303013 citedByCount "40" @default.
• W2113303013 countsByYear W21133030132015 @default.
• W2113303013 countsByYear W21133030132016 @default.
• W2113303013 countsByYear W21133030132017 @default.
• W2113303013 countsByYear W21133030132018 @default.
• W2113303013 countsByYear W21133030132019 @default.
• W2113303013 countsByYear W21133030132020 @default.
• W2113303013 countsByYear W21133030132021 @default.
• W2113303013 countsByYear W21133030132022 @default.
• W2113303013 countsByYear W21133030132023 @default.
• W2113303013 crossrefType "journal-article" @default.
• W2113303013 hasAuthorship W2113303013A5031343306 @default.
• W2113303013 hasAuthorship W2113303013A5038805652 @default.
• W2113303013 hasAuthorship W2113303013A5054443109 @default.
• W2113303013 hasAuthorship W2113303013A5060687805 @default.
• W2113303013 hasAuthorship W2113303013A5063649186 @default.
• W2113303013 hasAuthorship W2113303013A5073037534 @default.
• W2113303013 hasAuthorship W2113303013A5080903509 @default.
• W2113303013 hasAuthorship W2113303013A5081032810 @default.
• W2113303013 hasAuthorship W2113303013A5083591763 @default.
• W2113303013 hasBestOaLocation W21133030131 @default.
• W2113303013 hasConcept C104317684 @default.
• W2113303013 hasConcept C105580179 @default.
• W2113303013 hasConcept C150194340 @default.
• W2113303013 hasConcept C162317418 @default.
• W2113303013 hasConcept C165864922 @default.
• W2113303013 hasConcept C18431079 @default.

• next