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- W2113303165 abstract "ABSTRACT Host mitogen-activated protein kinases (MAPKs) are deregulated by herpes simplex virus 1 (HSV-1). Unlike p38 MAPK and Jun N-terminal protein kinase (JNK), which require ICP27 for their activation early in infection, extracellular signal-regulated kinase (ERK) activity is suppressed by an unknown mechanism. Here, we establish that HSV-1-induced suppression of ERK activity requires viral gene expression, occurs with delayed-early kinetics, and requires the functional virus-encoded Us3 Ser/Thr protein kinase. Finally, Us3 expression in uninfected cells was necessary and sufficient to suppress ERK activity in the absence of any other virus-encoded gene products. This demonstrates that inhibition of ERK activity in HSV-1-infected cells is an intrinsic Us3 function and defines a new role for this alphaherpesvirus Us3 kinase in regulating MAPK activation in infected cells." @default.
- W2113303165 created "2016-06-24" @default.
- W2113303165 creator A5026791436 @default.
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- W2113303165 date "2012-08-01" @default.
- W2113303165 modified "2023-10-16" @default.
- W2113303165 title "Suppression of Extracellular Signal-Regulated Kinase Activity in Herpes Simplex Virus 1-Infected Cells by the Us3 Protein Kinase" @default.
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- W2113303165 doi "https://doi.org/10.1128/jvi.00622-12" @default.
- W2113303165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3421675" @default.
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