FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113304701> ?p ?o ?g. }

• W2113304701 abstract "Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen(mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis." @default.
• W2113304701 created "2016-06-24" @default.
• W2113304701 creator A5020748592 @default.
• W2113304701 date "2014-07-01" @default.
• W2113304701 modified "2023-09-26" @default.
• W2113304701 title "Comprehensive molecular profiling of lung adenocarcinoma" @default.
• W2113304701 cites W1599357356 @default.
• W2113304701 cites W1931438814 @default.
• W2113304701 cites W1976963325 @default.
• W2113304701 cites W2000771269 @default.
• W2113304701 cites W2001962665 @default.
• W2113304701 cites W2005841680 @default.
• W2113304701 cites W2016341990 @default.
• W2113304701 cites W2017166332 @default.
• W2113304701 cites W2023171799 @default.
• W2113304701 cites W2023461603 @default.
• W2113304701 cites W2038014733 @default.
• W2113304701 cites W2042386784 @default.
• W2113304701 cites W2045883724 @default.
• W2113304701 cites W2049449785 @default.
• W2113304701 cites W2049674541 @default.
• W2113304701 cites W2071480068 @default.
• W2113304701 cites W2093357370 @default.
• W2113304701 cites W2096215586 @default.
• W2113304701 cites W2097413644 @default.
• W2113304701 cites W2104224322 @default.
• W2113304701 cites W2104830962 @default.
• W2113304701 cites W2108927999 @default.
• W2113304701 cites W2114031931 @default.
• W2113304701 cites W2115950635 @default.
• W2113304701 cites W2121262970 @default.
• W2113304701 cites W2122769974 @default.
• W2113304701 cites W2127443176 @default.
• W2113304701 cites W2130488043 @default.
• W2113304701 cites W2131876608 @default.
• W2113304701 cites W2132578211 @default.
• W2113304701 cites W2138601221 @default.
• W2113304701 cites W2141744105 @default.
• W2113304701 cites W2155379880 @default.
• W2113304701 cites W2156064049 @default.
• W2113304701 cites W2161446823 @default.
• W2113304701 cites W2161821474 @default.
• W2113304701 cites W2163798887 @default.
• W2113304701 cites W2170490448 @default.
• W2113304701 hasPublicationYear "2014" @default.
• W2113304701 type Work @default.
• W2113304701 sameAs 2113304701 @default.
• W2113304701 citedByCount "0" @default.
• W2113304701 crossrefType "journal-article" @default.
• W2113304701 hasAuthorship W2113304701A5020748592 @default.
• W2113304701 hasConcept C104317684 @default.
• W2113304701 hasConcept C105580179 @default.
• W2113304701 hasConcept C121608353 @default.
• W2113304701 hasConcept C134305767 @default.
• W2113304701 hasConcept C13514818 @default.
• W2113304701 hasConcept C142724271 @default.
• W2113304701 hasConcept C153911025 @default.
• W2113304701 hasConcept C194583182 @default.
• W2113304701 hasConcept C2776256026 @default.
• W2113304701 hasConcept C2781182431 @default.
• W2113304701 hasConcept C2781187634 @default.
• W2113304701 hasConcept C36823959 @default.
• W2113304701 hasConcept C501734568 @default.
• W2113304701 hasConcept C502942594 @default.
• W2113304701 hasConcept C54355233 @default.
• W2113304701 hasConcept C54458228 @default.
• W2113304701 hasConcept C67705224 @default.
• W2113304701 hasConcept C71924100 @default.
• W2113304701 hasConcept C86803240 @default.
• W2113304701 hasConceptScore W2113304701C104317684 @default.
• W2113304701 hasConceptScore W2113304701C105580179 @default.
• W2113304701 hasConceptScore W2113304701C121608353 @default.
• W2113304701 hasConceptScore W2113304701C134305767 @default.
• W2113304701 hasConceptScore W2113304701C13514818 @default.
• W2113304701 hasConceptScore W2113304701C142724271 @default.
• W2113304701 hasConceptScore W2113304701C153911025 @default.
• W2113304701 hasConceptScore W2113304701C194583182 @default.
• W2113304701 hasConceptScore W2113304701C2776256026 @default.
• W2113304701 hasConceptScore W2113304701C2781182431 @default.
• W2113304701 hasConceptScore W2113304701C2781187634 @default.
• W2113304701 hasConceptScore W2113304701C36823959 @default.
• W2113304701 hasConceptScore W2113304701C501734568 @default.
• W2113304701 hasConceptScore W2113304701C502942594 @default.
• W2113304701 hasConceptScore W2113304701C54355233 @default.
• W2113304701 hasConceptScore W2113304701C54458228 @default.
• W2113304701 hasConceptScore W2113304701C67705224 @default.
• W2113304701 hasConceptScore W2113304701C71924100 @default.
• W2113304701 hasConceptScore W2113304701C86803240 @default.
• W2113304701 hasLocation W21133047011 @default.
• W2113304701 hasOpenAccess W2113304701 @default.
• W2113304701 hasPrimaryLocation W21133047011 @default.
• W2113304701 hasRelatedWork W1977269166 @default.
• W2113304701 hasRelatedWork W2029155774 @default.
• W2113304701 hasRelatedWork W2038014733 @default.
• W2113304701 hasRelatedWork W2049243183 @default.
• W2113304701 hasRelatedWork W2071480068 @default.
• W2113304701 hasRelatedWork W2100754752 @default.
• W2113304701 hasRelatedWork W2180481128 @default.
• W2113304701 hasRelatedWork W2262414037 @default.
• W2113304701 hasRelatedWork W2275877493 @default.

• next