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- W2113305191 abstract "To assess the frequency and degree of hepatic dysfunction in patients with dengue infection, records of 214 serologically confirmed cases of dengue infection with available biochemical liver tests, admitted to our tertiary-care institute, were analysed. Patients were classified as classical dengue fever (DF) – 81.3%, dengue haemorrhagic fever (DHF) – 13.6% and dengue shock syndrome (DSS) – 5.1%. The mean age was 31.6 years (male:female = 3.3:1). Deranged total bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin and prothrombin time index (PTI) [international normalized ratio (INR)] was present in 19.5% (29/143), 97.7% (209/214), 93.9% (199/214), 32.6% (47/144), 29.1% (44/151) and 15.5% (22/156) patients respectively. The mean (± SE) total bilirubin, AST, ALT, ALP, albumin and INR values were 0.93 ± 0.09 mg/dl, 353.7 ± 49.6 U/L, 218.6 ± 27.2 U/L, 135.2 ± 6.5 U/L, 3.2 ± 0.04 g/dl and 1.2 ± 0.03 respectively. The mean value of AST was significantly higher than ALT. The degree of rise of AST and ALP was significantly more in DHF and DSS, as compared to DF; but the frequency of rise was similar in all groups. Mean serum bilirubin, ALT and ALP values were significantly higher in patients with haemorrhage as compared to those without haemorrhage, in patients with secondary dengue infection as compared to primary infection, and in non-survivors. Hepatic dysfunction was very common in all forms of dengue infection, with AST rising significantly more than ALT. Serum bilirubin, ALT and ALP were significantly higher in patients with DSS, haemorrhage, sequential infection and non-survivors. While preferentially high AST may serve as an early indicator of dengue infection, high bilirubin, ALT and ALP may act as poor prognostic markers." @default.
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- W2113305191 date "2008-01-01" @default.
- W2113305191 modified "2023-09-27" @default.
- W2113305191 title "Liver function tests in patients with dengue viral infection" @default.
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