FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113306142> ?p ?o ?g. }

• W2113306142 endingPage "1476" @default.
• W2113306142 startingPage "1470" @default.
• W2113306142 abstract "Abstract Background: A new parathyroid hormone (PTH) species, the N-terminal PTH form (N-PTH), is distinct from intact human PTH of 84 amino acid residues [hPTH(1–84)] and is recognized in a 3rd-generation assay of “whole” PTH (wPTH; the 1–2 epitope) but not in a 2nd-generation assay of “total” PTH (tPTH; the 12–18 epitope). N-PTH usually represents &lt;15% of wPTH but can be overproduced in severe primary hyperparathyroidism (PHPT) and secondary hyperparathyroidism. We investigated whether N-PTH is also overproduced in parathyroid cancer and whether N-PTH concentration is influenced by calcimimetic therapy. Methods: We studied 8 patients with parathyroid carcinoma before and at week 16 of cinacalcet therapy, 6 patients with PHPT, and 6 control individuals. We fractionated sera with HPLC and analyzed fractions with the 2 assays to quantify hPTH(1–84), N-PTH, and non-(1–84) PTH fragments. Results: Half of parathyroid carcinoma patients had an increased wPTH:tPTH ratio [mean (SD), 1.35 (0.29)]; the others had a typical ratio [0.72 (0.12)]. HPLC fractionation of sera from 2 high-ratio patients confirmed N-PTH overproduction [65% (12%) of wPTH]. The N-PTH fraction was &lt;15% of wPTH in PHPT and healthy individuals. Calcimimetic therapy appreciably reduced calcium concentrations in parathyroid carcinoma patients but had little influence on PTH concentration, the wPTH:tPTH ratio, or the PTH HPLC profile. Conclusion: N-PTH is overproduced in some parathyroid cancer patients, but calcimimetic therapy does not influence its production. The clinical implications of this finding in parathyroid carcinoma await additional studies with an emphasis on N-PTH’s biological activity and with larger numbers of patients." @default.
• W2113306142 created "2016-06-24" @default.
• W2113306142 creator A5003847350 @default.
• W2113306142 creator A5013126573 @default.
• W2113306142 creator A5019395470 @default.
• W2113306142 creator A5023085493 @default.
• W2113306142 creator A5034326980 @default.
• W2113306142 creator A5070617720 @default.
• W2113306142 creator A5071077441 @default.
• W2113306142 creator A5089834841 @default.
• W2113306142 date "2007-08-01" @default.
• W2113306142 modified "2023-09-27" @default.
• W2113306142 title "An N-Terminal Molecular Form of Parathyroid Hormone (PTH) Distinct from hPTH(1–84) Is Overproduced in Parathyroid Carcinoma" @default.
• W2113306142 cites W1555403659 @default.
• W2113306142 cites W2067704553 @default.
• W2113306142 cites W2074455854 @default.
• W2113306142 cites W2079730042 @default.
• W2113306142 cites W2104812689 @default.
• W2113306142 cites W2116094000 @default.
• W2113306142 cites W2122172605 @default.
• W2113306142 cites W2158070874 @default.
• W2113306142 cites W2161392852 @default.
• W2113306142 cites W2317369651 @default.
• W2113306142 cites W2338457994 @default.
• W2113306142 doi "https://doi.org/10.1373/clinchem.2007.085506" @default.
• W2113306142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17599957" @default.
• W2113306142 hasPublicationYear "2007" @default.
• W2113306142 type Work @default.
• W2113306142 sameAs 2113306142 @default.
• W2113306142 citedByCount "77" @default.
• W2113306142 countsByYear W21133061422012 @default.
• W2113306142 countsByYear W21133061422013 @default.
• W2113306142 countsByYear W21133061422014 @default.
• W2113306142 countsByYear W21133061422015 @default.
• W2113306142 countsByYear W21133061422016 @default.
• W2113306142 countsByYear W21133061422017 @default.
• W2113306142 countsByYear W21133061422018 @default.
• W2113306142 countsByYear W21133061422019 @default.
• W2113306142 countsByYear W21133061422020 @default.
• W2113306142 countsByYear W21133061422021 @default.
• W2113306142 countsByYear W21133061422022 @default.
• W2113306142 countsByYear W21133061422023 @default.
• W2113306142 crossrefType "journal-article" @default.
• W2113306142 hasAuthorship W2113306142A5003847350 @default.
• W2113306142 hasAuthorship W2113306142A5013126573 @default.
• W2113306142 hasAuthorship W2113306142A5019395470 @default.
• W2113306142 hasAuthorship W2113306142A5023085493 @default.
• W2113306142 hasAuthorship W2113306142A5034326980 @default.
• W2113306142 hasAuthorship W2113306142A5070617720 @default.
• W2113306142 hasAuthorship W2113306142A5071077441 @default.
• W2113306142 hasAuthorship W2113306142A5089834841 @default.
• W2113306142 hasBestOaLocation W21133061421 @default.
• W2113306142 hasConcept C126322002 @default.
• W2113306142 hasConcept C134018914 @default.
• W2113306142 hasConcept C185592680 @default.
• W2113306142 hasConcept C2775945674 @default.
• W2113306142 hasConcept C2777919317 @default.
• W2113306142 hasConcept C2778838027 @default.
• W2113306142 hasConcept C2779053571 @default.
• W2113306142 hasConcept C2780280601 @default.
• W2113306142 hasConcept C2780534505 @default.
• W2113306142 hasConcept C2781208988 @default.
• W2113306142 hasConcept C519063684 @default.
• W2113306142 hasConcept C71924100 @default.
• W2113306142 hasConceptScore W2113306142C126322002 @default.
• W2113306142 hasConceptScore W2113306142C134018914 @default.
• W2113306142 hasConceptScore W2113306142C185592680 @default.
• W2113306142 hasConceptScore W2113306142C2775945674 @default.
• W2113306142 hasConceptScore W2113306142C2777919317 @default.
• W2113306142 hasConceptScore W2113306142C2778838027 @default.
• W2113306142 hasConceptScore W2113306142C2779053571 @default.
• W2113306142 hasConceptScore W2113306142C2780280601 @default.
• W2113306142 hasConceptScore W2113306142C2780534505 @default.
• W2113306142 hasConceptScore W2113306142C2781208988 @default.
• W2113306142 hasConceptScore W2113306142C519063684 @default.
• W2113306142 hasConceptScore W2113306142C71924100 @default.
• W2113306142 hasFunder F4320332161 @default.
• W2113306142 hasFunder F4320334506 @default.
• W2113306142 hasFunder F4320337357 @default.
• W2113306142 hasIssue "8" @default.
• W2113306142 hasLocation W21133061421 @default.
• W2113306142 hasLocation W21133061422 @default.
• W2113306142 hasLocation W21133061423 @default.
• W2113306142 hasOpenAccess W2113306142 @default.
• W2113306142 hasPrimaryLocation W21133061421 @default.
• W2113306142 hasRelatedWork W1966238058 @default.
• W2113306142 hasRelatedWork W1967923169 @default.
• W2113306142 hasRelatedWork W2010449679 @default.
• W2113306142 hasRelatedWork W2105314539 @default.
• W2113306142 hasRelatedWork W2113306142 @default.
• W2113306142 hasRelatedWork W2133709292 @default.
• W2113306142 hasRelatedWork W2146468369 @default.
• W2113306142 hasRelatedWork W2397252022 @default.
• W2113306142 hasRelatedWork W2401052199 @default.
• W2113306142 hasRelatedWork W2765230403 @default.
• W2113306142 hasVolume "53" @default.
• W2113306142 isParatext "false" @default.
• W2113306142 isRetracted "false" @default.

• next