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- W2113307967 abstract "Endogenous opioid systems have been implicated in the consequences of social isolation and in the regulation of social behavior, although their precise role is not clear. There is not much information on a possible locus in the brain at which opioids exert their effects on social behavior. In an effort to address this issue we analyzed regional opioidergic activity upon social isolation-induced social interaction using in vivo autoradiography. Animals were either socially isolated for 7 days or group housed, and tested singly or in a dyadic encounter. Subsequently, a tracer dose of [3H]diprenorphine was administered and in vivo autoradiographic analysis was performed. Seven days of social isolation caused changes in both social behavior (dyadic encounters) and non-social behavior (singly tested animals). Opioid receptor binding was increased in the medial prefrontal cortex and the parafascicular area in isolates, suggesting that social isolation may evoke an upregulation of opioid receptors in these areas. Social interaction increased opioid binding in the parafascicular area of non-isolated rats. In substantia nigra para compacta and ventral tegmental area binding was increased upon social isolation, and social interaction decreased opioid binding in isolates, but these changes failed to reach significance. These observed local changes in opioid receptor binding suggest a role for opioid systems in discrete areas in the consequences of social isolation and the regulation of social behavior in rats." @default.
- W2113307967 created "2016-06-24" @default.
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- W2113307967 date "1995-06-01" @default.
- W2113307967 modified "2023-09-27" @default.
- W2113307967 title "Social isolation and social interaction alter regional brain opioid receptor binding in rats" @default.
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- W2113307967 doi "https://doi.org/10.1016/0924-977x(95)00010-m" @default.
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