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• W2113308002 abstract "Purpose: To investigate the effect of intravitreal bevacizumab (IVB) combined with intravitreal high-dose triamcinolone acetonide (IVTA) for therapy of exudative age-related macular degeneration (AMD) after unsuccessful IVB monotherapy. Methods: The prospective study included 29 White patients (31 eyes) who consecutively received IVB (1.5 mg) plus high-dose IVTA (20–25 mg) for exudative AMD, after they had received multiple IVB mono-injections without functional and anatomical success. Two additional IVB injections were given in intervals of 2 months after the combined injection. The main outcome parameters were best-corrected visual acuity (BCVA) and data measured by optic coherence tomography (OCT). Results: Mean BCVA (LogMAR) improved from 0.70 ± 0.37 LogMAR at baseline to 0.59 ± 0.38 LogMAR at 2 months after first follow-up (P = 0.004) and to 0.63 ± 0.41 LogMAR (P = 0.04) at 4 months after baseline. It deteriorated to 0.68 ± 0.41 at the end of the follow-up at 7 months after the combined injection, without a significant (P = 0.53) difference to the baseline visual acuity. The maximum macular thickness decreased significantly from 371 ± 206 μm at baseline to 322 ± 90 μm (P = 0.04) at the first follow-up and to 316 ± 90 μm (P = 0.03) at the second follow-up. It slightly increased toward the end of follow-up (333 ± 133 μm; P = 0.16). Intraocular pressure increased marginally significantly (P = 0.06) from 14.5 ± 2.8 mm Hg to 15.7 ± 3.3 mm Hg at the second follow-up. Conclusions: Patients with exudative AMD, in whom monotherapy with IVB was unsuccessful, may experience a temporary improvement in vision and reduction in macular thickness after a combined intravitreal injection of bevacizumab and triamcinolone." @default.
• W2113308002 created "2016-06-24" @default.
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• W2113308002 date "2010-04-01" @default.
• W2113308002 modified "2023-09-26" @default.
• W2113308002 title "Intravitreal Bevacizumab Combined With Intravitreal Triamcinolone for Therapy-Resistant Exudative Age-Related Macular Degeneration" @default.
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• W2113308002 doi "https://doi.org/10.1089/jop.2009.0131" @default.
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