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• W2113313806 abstract "RENAL DYSFUNCTION IS ONE OF the most serious organ complications of cardiac surgery. It appears to be common in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). 1 Aronson S. Blumenthal R. Perioperative renal dysfunction and cardiovascular anesthesia: Concerns and controversies. J Cardiothorac Vasc Anesth. 1998; 12: 567-586 Abstract Full Text PDF PubMed Scopus (95) Google Scholar Of the approximately 600,000 patients undergoing coronary revascularization per year in the United States, 1.1% to 1.4% develop postoperative acute renal failure (ARF) requiring dialysis. 2 Simmons P.I. Anderson R.J. Increased serum creatinine: A marker for adverse outcome before and after cardiac surgery. Crit Care Med. 2002; 30: 1664-1665 Crossref PubMed Scopus (13) Google Scholar Many more patients suffer from occult, subclinical, and transient renal injury without requiring hemodialysis. 2 Simmons P.I. Anderson R.J. Increased serum creatinine: A marker for adverse outcome before and after cardiac surgery. Crit Care Med. 2002; 30: 1664-1665 Crossref PubMed Scopus (13) Google Scholar ARF after cardiac surgery is an independent predictor of mortality, and even renal dysfunction not requiring dialysis appears to be an independent predictor of mortality in this situation. 1 Aronson S. Blumenthal R. Perioperative renal dysfunction and cardiovascular anesthesia: Concerns and controversies. J Cardiothorac Vasc Anesth. 1998; 12: 567-586 Abstract Full Text PDF PubMed Scopus (95) Google Scholar , 3 Conlon P.J. Stafford-Smith M. White W.D. et al. Acute renal failure following cardiac surgery. Nephrol Dial Transplant. 1999; 14: 1158-1162 Crossref PubMed Scopus (506) Google Scholar , 4 Yallop K.G. Smith D. The incidence and pathogenesis of acute renal failure following cardiac surgery, and strategies for its prevention. Ann Cardiac Anaesth. 2004; 7: 17-31 PubMed Google Scholar Mortality in cardiac surgery patients developing ARF requiring hemodialysis is approximately 10% to 20%, compared with a 1% mortality in patients without ARF. 3 Conlon P.J. Stafford-Smith M. White W.D. et al. Acute renal failure following cardiac surgery. Nephrol Dial Transplant. 1999; 14: 1158-1162 Crossref PubMed Scopus (506) Google Scholar In addition, ARF with dialysis increases in-hospital stay 2- to 3-fold resulting in increased costs. 4 Yallop K.G. Smith D. The incidence and pathogenesis of acute renal failure following cardiac surgery, and strategies for its prevention. Ann Cardiac Anaesth. 2004; 7: 17-31 PubMed Google Scholar There is increasing evidence that small decreases in kidney function are important for patients’ outcome as well. Chertow et al 5 Chertow G.M. Burdick E. Honour M. et al. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005; 16: 3365-3370 Crossref PubMed Scopus (2549) Google Scholar defined kidney dysfunction as an increase of serum creatinine >0.3 mg/dL and found this was independently associated with mortality. In a prospective cohort study in cardiac surgery patients, Lassnigg et al 6 Lassnigg A. Schmidlin D. Mouhieddine M. et al. Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: A prospective cohort study. J Am Soc Nephrol. 2004; 15: 1597-1605 Crossref PubMed Scopus (1105) Google Scholar showed that acute kidney dysfunction, defined as an increase of serum creatinine of 0.5 mg/dL or above was associated with worse survival." @default.
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• W2113313806 date "2008-02-01" @default.
• W2113313806 modified "2023-09-23" @default.
• W2113313806 title "Identification of Renal Injury in Cardiac Surgery: The Role of Kidney-Specific Proteins" @default.
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• W2113313806 doi "https://doi.org/10.1053/j.jvca.2007.10.008" @default.
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