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- W2113320375 abstract "The composition of the ECM provides contextual cues to leukocytes in inflamed and healing tissues. One example of this is HA, where LMW-HA, generated during active inflammation, is a TLR ligand and an endogenous danger signal, and HMW-HA, predominant in healing or intact tissues, functions in an inverse manner. Our data suggest that HMW-HA actively promotes immune tolerance by augmenting CD4+CD25+ T(Reg) function, and LMW-HA does not. Using a human iT(Reg) model, we demonstrate that HMW-HA but not LMW-HA provides a costimulatory signal through cross-linking CD44 which promotes Foxp3 expression, a critical signaling molecule associated with T(Reg). This effect, in part, may be mediated by a role for intact HMW-HA in IL-2 production, as T(Reg) are highly IL-2-dependent for their survival and function. We propose that HMW-HA contributes to the maintenance of immune homeostasis in uninjured tissue and effectively communicates an all-clear signal to down-regulate the adaptive immune system through T(Reg) after tissue matrix integrity has been restored." @default.
- W2113320375 created "2016-06-24" @default.
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- W2113320375 date "2009-04-28" @default.
- W2113320375 modified "2023-10-12" @default.
- W2113320375 title "Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells" @default.
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- W2113320375 doi "https://doi.org/10.1189/jlb.0109001" @default.
- W2113320375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2735281" @default.
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