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- W2113331331 abstract "The current developments in liquid chromatography-mass spectrometry (LC-MS) and its applications to the analysis of pharmaceuticals are reviewed. Various mass spectrometric techniques, including electrospray and nanospray ionization, atmospheric pressure chemical ionization and photoionization and their interface with liquid chromatographic techniques are described. These include high performance liquid chromatography, capillary electrophoresis and capillary electrochromatography and the advantages and disadvantages of each technique are discussed. The applications of LC-MS to the studies of in vitro and in vivo drug metabolism, identification and characterization of impurities in pharmaceuticals, analysis of chiral impurities in drug substances and high-throughput LC-MS-MS systems for applications in the “accelerated drug discovery” process are described." @default.
- W2113331331 created "2016-06-24" @default.
- W2113331331 creator A5018505765 @default.
- W2113331331 creator A5070352874 @default.
- W2113331331 date "2002-01-01" @default.
- W2113331331 modified "2023-10-01" @default.
- W2113331331 title "Current Developments in LC-MS for Pharmaceutical Analysis" @default.
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- W2113331331 doi "https://doi.org/10.1248/bpb.25.547" @default.
- W2113331331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12033491" @default.
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