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• W2113341180 abstract "During the past decade, a series of clinical trials of 3-hydroxy-3 methylglutaryl coenzyme A (statins) have demonstrated significant reductions in recurrent myocardial infarction, stroke, and death for both primary and secondary prevention of coronary heart disease (CHD) ( 1 Cheung B.M. Lauder I.J. Lau C.P. Kumana C.R. Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes. Br J Clin Pharmacol. 2004; 57: 640-651 Google Scholar ). The widespread use of statins is expected to revolutionize the treatment of hypercholesterolemia and cardiovascular disease (CVD). However, with the increasing epidemic of obesity and type 2 diabetes, the worldwide burden of CVD will continue to grow. Although treatment with effective drugs like statins can reduce cardiovascular risk, it is expensive, can have side effects, and often must be continued for a lifetime. It is unrealistic to expect that improved treatment and technology will halt and reverse the obesity epidemic and reduce the global burden of CVD and other chronic conditions. F. B. Hu is an associate professor of Nutrition and Epidemiology with the Departments of Nutrition and Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA." @default.
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• W2113341180 date "2005-11-01" @default.
• W2113341180 modified "2023-09-27" @default.
• W2113341180 title "The Role of Diet and Lifestyle Modifications in the Statin Era" @default.
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• W2113341180 doi "https://doi.org/10.1016/j.jada.2005.09.027" @default.
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