FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113354406> ?p ?o ?g. }

• W2113354406 endingPage "1195" @default.
• W2113354406 startingPage "1179" @default.
• W2113354406 abstract "Protein ubiquitylation and sumoylation play key roles in regulating cellular responses to DNA double-strand breaks (DSBs). Here, we show that human RNF4, a small ubiquitin-like modifier (SUMO)-targeted ubiquitin E3 ligase, is recruited to DSBs in a manner requiring its SUMO interaction motifs, the SUMO E3 ligases PIAS1 and PIAS4, and various DSB-responsive proteins. Furthermore, we reveal that RNF4 depletion impairs ubiquitin adduct formation at DSB sites and causes persistent histone H2AX phosphorylation (γH2AX) associated with defective DSB repair, hypersensitivity toward DSB-inducing agents, and delayed recovery from radiation-induced cell cycle arrest. We establish that RNF4 regulates turnover of the DSB-responsive factors MDC1 and replication protein A (RPA) at DNA damage sites and that RNF4-depleted cells fail to effectively replace RPA by the homologous recombination factors BRCA2 and RAD51 on resected DNA. Consistent with previous data showing that RNF4 targets proteins to the proteasome, we show that the proteasome component PSMD4 is recruited to DNA damage sites in a manner requiring its ubiquitin-interacting domains, RNF4 and RNF8. Finally, we establish that PSMD4 binds MDC1 and RPA1 in a DNA damage-induced, RNF4-dependent manner and that PSMD4 depletion cause MDC1 and γH2AX persistence in irradiated cells. RNF4 thus operates as a DSB response factor at the crossroads between the SUMO and ubiquitin systems." @default.
• W2113354406 created "2016-06-24" @default.
• W2113354406 creator A5028157175 @default.
• W2113354406 creator A5061795154 @default.
• W2113354406 creator A5072872049 @default.
• W2113354406 creator A5082694913 @default.
• W2113354406 date "2012-06-01" @default.
• W2113354406 modified "2023-10-12" @default.
• W2113354406 title "RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair" @default.
• W2113354406 cites W1966805549 @default.
• W2113354406 cites W1967630574 @default.
• W2113354406 cites W1968552183 @default.
• W2113354406 cites W1970445060 @default.
• W2113354406 cites W1970488978 @default.
• W2113354406 cites W1973030224 @default.
• W2113354406 cites W1974755980 @default.
• W2113354406 cites W1979385111 @default.
• W2113354406 cites W1981816841 @default.
• W2113354406 cites W1985165882 @default.
• W2113354406 cites W1989643386 @default.
• W2113354406 cites W1993442317 @default.
• W2113354406 cites W1994218254 @default.
• W2113354406 cites W1998499862 @default.
• W2113354406 cites W1999541392 @default.
• W2113354406 cites W2002520178 @default.
• W2113354406 cites W2005833414 @default.
• W2113354406 cites W2007919127 @default.
• W2113354406 cites W2021044341 @default.
• W2113354406 cites W2022912676 @default.
• W2113354406 cites W2025331058 @default.
• W2113354406 cites W2028154024 @default.
• W2113354406 cites W2039143648 @default.
• W2113354406 cites W2039501969 @default.
• W2113354406 cites W2043895957 @default.
• W2113354406 cites W2044229112 @default.
• W2113354406 cites W2044287615 @default.
• W2113354406 cites W2052547134 @default.
• W2113354406 cites W2054782539 @default.
• W2113354406 cites W2055761018 @default.
• W2113354406 cites W2058367800 @default.
• W2113354406 cites W2058471321 @default.
• W2113354406 cites W2059731486 @default.
• W2113354406 cites W2061462200 @default.
• W2113354406 cites W2072150230 @default.
• W2113354406 cites W2076170552 @default.
• W2113354406 cites W2077436902 @default.
• W2113354406 cites W2078046348 @default.
• W2113354406 cites W2078544177 @default.
• W2113354406 cites W2084034209 @default.
• W2113354406 cites W2085544302 @default.
• W2113354406 cites W2088461960 @default.
• W2113354406 cites W2089130084 @default.
• W2113354406 cites W2093984973 @default.
• W2113354406 cites W2096626023 @default.
• W2113354406 cites W2097824787 @default.
• W2113354406 cites W2098380763 @default.
• W2113354406 cites W2100200896 @default.
• W2113354406 cites W2102107922 @default.
• W2113354406 cites W2104396972 @default.
• W2113354406 cites W2106225536 @default.
• W2113354406 cites W2106624609 @default.
• W2113354406 cites W2110817748 @default.
• W2113354406 cites W2114776482 @default.
• W2113354406 cites W2116017702 @default.
• W2113354406 cites W2117602431 @default.
• W2113354406 cites W2131827278 @default.
• W2113354406 cites W2132396299 @default.
• W2113354406 cites W2139538368 @default.
• W2113354406 cites W2145200068 @default.
• W2113354406 cites W2152440925 @default.
• W2113354406 cites W2157585438 @default.
• W2113354406 cites W2157899948 @default.
• W2113354406 cites W2168588359 @default.
• W2113354406 cites W2323640443 @default.
• W2113354406 cites W4230719601 @default.
• W2113354406 cites W95252060 @default.
• W2113354406 doi "https://doi.org/10.1101/gad.188284.112" @default.
• W2113354406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3371407" @default.
• W2113354406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22661229" @default.
• W2113354406 hasPublicationYear "2012" @default.
• W2113354406 type Work @default.
• W2113354406 sameAs 2113354406 @default.
• W2113354406 citedByCount "268" @default.
• W2113354406 countsByYear W21133544062012 @default.
• W2113354406 countsByYear W21133544062013 @default.
• W2113354406 countsByYear W21133544062014 @default.
• W2113354406 countsByYear W21133544062015 @default.
• W2113354406 countsByYear W21133544062016 @default.
• W2113354406 countsByYear W21133544062017 @default.
• W2113354406 countsByYear W21133544062018 @default.
• W2113354406 countsByYear W21133544062019 @default.
• W2113354406 countsByYear W21133544062020 @default.
• W2113354406 countsByYear W21133544062021 @default.
• W2113354406 countsByYear W21133544062022 @default.
• W2113354406 countsByYear W21133544062023 @default.
• W2113354406 crossrefType "journal-article" @default.
• W2113354406 hasAuthorship W2113354406A5028157175 @default.
• W2113354406 hasAuthorship W2113354406A5061795154 @default.

• next