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• W2113374218 abstract "Interaction of nanoparticles with human cells is an interesting topic for understanding toxicity and developing potential drug candidates. Water soluble platinum nanoparticles were synthesized via reduction of hexachloroplatinic acid using sodium borohydride in the presence of capping agents. The bioactivity of folic acid and poly(vinyl pyrrolidone) capped platinum nanoparticles (Pt-nps) has been investigated using commercially available cell lines. In the cell viability experiments, PVP-capped nanoparticles were found to be less toxic (>80% viability), whereas, folic acid-capped platinum nanoparticles showed a reduced viability down to 24% after 72 h of exposure at a concentration of 100 μg ml(-1) for MCF7 breast cancer cells. Such toxicity, combined with the possibility to incorporate functional organic molecules as capping agents, can be used for developing new drug candidates." @default.
• W2113374218 created "2016-06-24" @default.
• W2113374218 creator A5033497521 @default.
• W2113374218 creator A5091882478 @default.
• W2113374218 date "2010-01-01" @default.
• W2113374218 modified "2023-10-02" @default.
• W2113374218 title "Active targeting of cancer cells using folic acid-conjugated platinum nanoparticles" @default.
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• W2113374218 doi "https://doi.org/10.1039/c0nr00204f" @default.
• W2113374218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20936240" @default.
• W2113374218 hasPublicationYear "2010" @default.
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