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• W2113379516 endingPage "736" @default.
• W2113379516 startingPage "719" @default.
• W2113379516 abstract "In February 2010, the U.S. Food and Drug Administration (FDA, 2010 ) drafted guidance that discusses the statistical, clinical, and regulatory aspects of various adaptive designs for clinical trials. An important class of adaptive designs is adaptive randomization, which is considered very briefly in subsection VI.B of the guidance. The objective of this paper is to review several important new classes of adaptive randomization procedures and convey information on the recent developments in the literature on this topic. Much of this literature has been focused on the development of methodology to address past criticisms and concerns that have hindered the broader use of adaptive randomization. We conclude that adaptive randomization is a very broad area of experimental design that has important application in modern clinical trials." @default.
• W2113379516 created "2016-06-24" @default.
• W2113379516 creator A5019969539 @default.
• W2113379516 creator A5040494856 @default.
• W2113379516 creator A5057483408 @default.
• W2113379516 date "2012-05-31" @default.
• W2113379516 modified "2023-09-30" @default.
• W2113379516 title "Adaptive Randomization for Clinical Trials" @default.
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