FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113402490> ?p ?o ?g. }

• W2113402490 endingPage "10692" @default.
• W2113402490 startingPage "10684" @default.
• W2113402490 abstract "For many envisioned applications of lentivirus vectors as tools in respiratory biology and therapeutic gene delivery, the efficiency of gene transfer must be improved. We previously demonstrated stable, persistent (>11 months) in vivo expression following a single application of a feline immunodeficiency virus (FIV)-based lentivirus vector (GP64-FIV) to murine nasal epithelia. Here we investigate the efficacy of repeated administration of lentivirus vectors to the airways. Using quantitative bioluminescent imaging, we found that consecutive daily dosing achieved a linear increase in gene expression and greatly increased the number of epithelial cells targeted. Surprisingly, reporter gene expression also increased additively following each of seven doses of FIV delivered over consecutive weeks (1 dose/week), without the development of systemic or local neutralizing antibodies. This approach enhanced expression of both reporter and therapeutic transgenes. Transduction efficiency achieved following a single dose of FIV expressing mouse erythropoietin was insufficient to increase hematocrit, whereas seven consecutive daily doses significantly increased hematocrit. These unexpected results contrast strikingly with findings reported for adenovirus vectors. Prolonged gene expression has been observed in vivo following a single dose of virus vector; however, depending on the application, repeated administration of vector may be necessary to achieve stable, therapeutic gene expression." @default.
• W2113402490 created "2016-06-24" @default.
• W2113402490 creator A5006078912 @default.
• W2113402490 creator A5028322068 @default.
• W2113402490 creator A5059821728 @default.
• W2113402490 creator A5085725734 @default.
• W2113402490 date "2008-11-01" @default.
• W2113402490 modified "2023-10-01" @default.
• W2113402490 title "Lentivirus Vector Can Be Readministered to Nasal Epithelia without Blocking Immune Responses" @default.
• W2113402490 cites W1485992471 @default.
• W2113402490 cites W1491436713 @default.
• W2113402490 cites W1963799836 @default.
• W2113402490 cites W1965738207 @default.
• W2113402490 cites W1967499306 @default.
• W2113402490 cites W1967670116 @default.
• W2113402490 cites W1968469725 @default.
• W2113402490 cites W1970638821 @default.
• W2113402490 cites W1971025152 @default.
• W2113402490 cites W1971837501 @default.
• W2113402490 cites W1972244141 @default.
• W2113402490 cites W1973292232 @default.
• W2113402490 cites W1979152477 @default.
• W2113402490 cites W1981259148 @default.
• W2113402490 cites W2009994978 @default.
• W2113402490 cites W2010303814 @default.
• W2113402490 cites W2012104351 @default.
• W2113402490 cites W2013911193 @default.
• W2113402490 cites W2018457584 @default.
• W2113402490 cites W2030965101 @default.
• W2113402490 cites W2046370726 @default.
• W2113402490 cites W2048324572 @default.
• W2113402490 cites W2050888866 @default.
• W2113402490 cites W2061752094 @default.
• W2113402490 cites W2062929761 @default.
• W2113402490 cites W2065422942 @default.
• W2113402490 cites W2065593770 @default.
• W2113402490 cites W2073316972 @default.
• W2113402490 cites W2076157508 @default.
• W2113402490 cites W2080162608 @default.
• W2113402490 cites W2086866768 @default.
• W2113402490 cites W2100749737 @default.
• W2113402490 cites W2101605345 @default.
• W2113402490 cites W2116264090 @default.
• W2113402490 cites W2125160350 @default.
• W2113402490 cites W2131095976 @default.
• W2113402490 cites W2145604558 @default.
• W2113402490 cites W2147823227 @default.
• W2113402490 cites W2148019580 @default.
• W2113402490 cites W2156119419 @default.
• W2113402490 cites W2166527397 @default.
• W2113402490 cites W2178247330 @default.
• W2113402490 cites W4233745600 @default.
• W2113402490 doi "https://doi.org/10.1128/jvi.00227-08" @default.
• W2113402490 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2573216" @default.
• W2113402490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18768988" @default.
• W2113402490 hasPublicationYear "2008" @default.
• W2113402490 type Work @default.
• W2113402490 sameAs 2113402490 @default.
• W2113402490 citedByCount "88" @default.
• W2113402490 countsByYear W21134024902012 @default.
• W2113402490 countsByYear W21134024902013 @default.
• W2113402490 countsByYear W21134024902014 @default.
• W2113402490 countsByYear W21134024902015 @default.
• W2113402490 countsByYear W21134024902016 @default.
• W2113402490 countsByYear W21134024902017 @default.
• W2113402490 countsByYear W21134024902018 @default.
• W2113402490 countsByYear W21134024902019 @default.
• W2113402490 countsByYear W21134024902020 @default.
• W2113402490 countsByYear W21134024902021 @default.
• W2113402490 countsByYear W21134024902022 @default.
• W2113402490 countsByYear W21134024902023 @default.
• W2113402490 crossrefType "journal-article" @default.
• W2113402490 hasAuthorship W2113402490A5006078912 @default.
• W2113402490 hasAuthorship W2113402490A5028322068 @default.
• W2113402490 hasAuthorship W2113402490A5059821728 @default.
• W2113402490 hasAuthorship W2113402490A5085725734 @default.
• W2113402490 hasBestOaLocation W21134024901 @default.
• W2113402490 hasConcept C102230213 @default.
• W2113402490 hasConcept C104317684 @default.
• W2113402490 hasConcept C111599444 @default.
• W2113402490 hasConcept C135983454 @default.
• W2113402490 hasConcept C150194340 @default.
• W2113402490 hasConcept C15152581 @default.
• W2113402490 hasConcept C153911025 @default.
• W2113402490 hasConcept C159047783 @default.
• W2113402490 hasConcept C161733203 @default.
• W2113402490 hasConcept C203014093 @default.
• W2113402490 hasConcept C207001950 @default.
• W2113402490 hasConcept C2522874641 @default.
• W2113402490 hasConcept C2777841672 @default.
• W2113402490 hasConcept C2779690655 @default.
• W2113402490 hasConcept C2780727368 @default.
• W2113402490 hasConcept C32470452 @default.
• W2113402490 hasConcept C40767141 @default.
• W2113402490 hasConcept C54355233 @default.
• W2113402490 hasConcept C55493867 @default.
• W2113402490 hasConcept C86803240 @default.
• W2113402490 hasConcept C92087593 @default.

• next