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• W2113402542 endingPage "1065" @default.
• W2113402542 startingPage "1059" @default.
• W2113402542 abstract "New imidazo[1,2-a]pyrazine derivatives have been synthesized either by direct cyclization from pyrazines or by electrophilic substitutions. The presence of electron donating groups on position 8 greatly enhances the reactivity of the heterocycle towards such reactions on position 3 of the heterocycle. The activities of these derivatives in trachealis muscle relaxation and in inhibiting cyclic nucleotide phosphodiesterase (PDE) isoenzyme types III and IV have been assessed. All compounds demonstrated significantly higher relaxant potency than theophylline. All the derivatives were moderately potent in inhibiting the type IV isoenzyme of PDE but only those with a cyano group on position 2 were potent in inhibiting the type III isoenzyme." @default.
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• W2113402542 date "1999-06-01" @default.
• W2113402542 modified "2023-10-18" @default.
• W2113402542 title "New imidazo[1,2-a]pyrazine derivatives with bronchodilatory and cyclic nucleotide phosphodiesterase inhibitory activities" @default.
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• W2113402542 doi "https://doi.org/10.1016/s0968-0896(99)00019-x" @default.
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