FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113402551> ?p ?o ?g. }

• W2113402551 endingPage "1493" @default.
• W2113402551 startingPage "1483" @default.
• W2113402551 abstract "Accurate transmission of genetic material relies on the coupling of chromosomes to spindle microtubules by kinetochores. These linkages are regulated by the conserved Aurora B/Ipl1 kinase to ensure that sister chromatids are properly attached to spindle microtubules. Kinetochore-microtubule attachments require the essential Ndc80 complex, which contains two globular ends linked by large coiled-coil domains. In this study, we isolated a novel ndc80 mutant in Saccharomyces cerevisiae that contains mutations in the coiled-coil domain. This ndc80 mutant accumulates erroneous kinetochore-microtubule attachments, resulting in misalignment of kinetochores on the mitotic spindle. Genetic analyses with suppressors of the ndc80 mutant and in vitro cross-linking experiments suggest that the kinetochore misalignment in vivo stems from a defect in the ability of the Ndc80 complex to stably fold at a hinge in the coiled coil. Previous studies proposed that the Ndc80 complex can exist in multiple conformations: elongated during metaphase and bent during anaphase. However, the distinct functions of individual conformations in vivo are unknown. Here, our analysis revealed a tightly folded conformation of the Ndc80 complex that is likely required early in mitosis. This conformation is mediated by a direct, intracomplex interaction and involves a greater degree of folding than the bent form of the complex at anaphase. Furthermore, our results suggest that this conformation is functionally important in vivo for efficient error correction by Aurora B/Ipl1 and, consequently, to ensure proper kinetochore alignment early in mitosis." @default.
• W2113402551 created "2016-06-24" @default.
• W2113402551 creator A5007652748 @default.
• W2113402551 creator A5008666950 @default.
• W2113402551 creator A5018903678 @default.
• W2113402551 creator A5020725514 @default.
• W2113402551 creator A5022826364 @default.
• W2113402551 creator A5036737482 @default.
• W2113402551 creator A5037053192 @default.
• W2113402551 creator A5043959168 @default.
• W2113402551 creator A5061213874 @default.
• W2113402551 creator A5067746093 @default.
• W2113402551 creator A5074569982 @default.
• W2113402551 creator A5083768832 @default.
• W2113402551 date "2014-09-16" @default.
• W2113402551 modified "2023-10-16" @default.
• W2113402551 title "Kinetochore Biorientation in <i>Saccharomyces cerevisiae</i> Requires a Tightly Folded Conformation of the Ndc80 Complex" @default.
• W2113402551 cites W1764895571 @default.
• W2113402551 cites W1832847580 @default.
• W2113402551 cites W1961177618 @default.
• W2113402551 cites W1965813899 @default.
• W2113402551 cites W1968916548 @default.
• W2113402551 cites W1984112252 @default.
• W2113402551 cites W1990300808 @default.
• W2113402551 cites W1990586954 @default.
• W2113402551 cites W1997206295 @default.
• W2113402551 cites W1997535646 @default.
• W2113402551 cites W2017914102 @default.
• W2113402551 cites W2022046477 @default.
• W2113402551 cites W2027329338 @default.
• W2113402551 cites W2028604863 @default.
• W2113402551 cites W2031349427 @default.
• W2113402551 cites W2044990663 @default.
• W2113402551 cites W2045658203 @default.
• W2113402551 cites W2053943711 @default.
• W2113402551 cites W2055743739 @default.
• W2113402551 cites W2085165779 @default.
• W2113402551 cites W2086283062 @default.
• W2113402551 cites W2090834457 @default.
• W2113402551 cites W2107755102 @default.
• W2113402551 cites W2119108223 @default.
• W2113402551 cites W2120772351 @default.
• W2113402551 cites W2122956708 @default.
• W2113402551 cites W2127660818 @default.
• W2113402551 cites W2128918653 @default.
• W2113402551 cites W2130900200 @default.
• W2113402551 cites W2133503471 @default.
• W2113402551 cites W2136125398 @default.
• W2113402551 cites W2137015675 @default.
• W2113402551 cites W2157980476 @default.
• W2113402551 cites W2161239415 @default.
• W2113402551 cites W2165606404 @default.
• W2113402551 cites W2166102124 @default.
• W2113402551 cites W2169346900 @default.
• W2113402551 cites W2170145644 @default.
• W2113402551 doi "https://doi.org/10.1534/genetics.114.167775" @default.
• W2113402551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4256767" @default.
• W2113402551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25230952" @default.
• W2113402551 hasPublicationYear "2014" @default.
• W2113402551 type Work @default.
• W2113402551 sameAs 2113402551 @default.
• W2113402551 citedByCount "18" @default.
• W2113402551 countsByYear W21134025512015 @default.
• W2113402551 countsByYear W21134025512016 @default.
• W2113402551 countsByYear W21134025512017 @default.
• W2113402551 countsByYear W21134025512018 @default.
• W2113402551 countsByYear W21134025512019 @default.
• W2113402551 countsByYear W21134025512020 @default.
• W2113402551 countsByYear W21134025512022 @default.
• W2113402551 countsByYear W21134025512023 @default.
• W2113402551 crossrefType "journal-article" @default.
• W2113402551 hasAuthorship W2113402551A5007652748 @default.
• W2113402551 hasAuthorship W2113402551A5008666950 @default.
• W2113402551 hasAuthorship W2113402551A5018903678 @default.
• W2113402551 hasAuthorship W2113402551A5020725514 @default.
• W2113402551 hasAuthorship W2113402551A5022826364 @default.
• W2113402551 hasAuthorship W2113402551A5036737482 @default.
• W2113402551 hasAuthorship W2113402551A5037053192 @default.
• W2113402551 hasAuthorship W2113402551A5043959168 @default.
• W2113402551 hasAuthorship W2113402551A5061213874 @default.
• W2113402551 hasAuthorship W2113402551A5067746093 @default.
• W2113402551 hasAuthorship W2113402551A5074569982 @default.
• W2113402551 hasAuthorship W2113402551A5083768832 @default.
• W2113402551 hasBestOaLocation W21134025511 @default.
• W2113402551 hasConcept C104317684 @default.
• W2113402551 hasConcept C12554922 @default.
• W2113402551 hasConcept C141937037 @default.
• W2113402551 hasConcept C1491633281 @default.
• W2113402551 hasConcept C175732170 @default.
• W2113402551 hasConcept C192838845 @default.
• W2113402551 hasConcept C20418707 @default.
• W2113402551 hasConcept C2778354886 @default.
• W2113402551 hasConcept C29537977 @default.
• W2113402551 hasConcept C30481170 @default.
• W2113402551 hasConcept C47432576 @default.
• W2113402551 hasConcept C53420372 @default.
• W2113402551 hasConcept C54355233 @default.
• W2113402551 hasConcept C55988834 @default.

• next