FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113402877> ?p ?o ?g. }

• W2113402877 endingPage "570" @default.
• W2113402877 startingPage "563" @default.
• W2113402877 abstract "Background The need to develop predictive tests which could identify potential allergens has been recognized for many years. There is as yet no accepted in vitro method for the assessment of contact sensitizers. Objective We have tested the ability of a range of contact allergens to induce in vitro primary sensitization of autologous T cells. Method T-cell proliferation induced by haptens using 2-day cultured human Langerhans cells as antigen-presenting cell was assessed by 3H thymidine incorporation. Antigen specific stimulation was calculated as stimulation indexes. Results Strong allergens induced in vitro a primary T-cell response in all (trinitrophenyl, TNP: 13/13) or in the majority (fluorescein isothiocyanate, FITC: 7/10) of experiments. An irritant, sodium dodecyi sulfate (SDS). failed to generate a significant T-cell proliferation in any of the experiments (0/10). We obtained a significant lymphoproliferative response to weak sensitizers only in a limited number of experiments: (coumarin: 1/12, citronellal: 0/10, hydroxycitronellal: 2/8). p-Phenylenediamine (PPDA), a prohapten and highly sensitizing chemical in vivo, generated primary sensitization in vitro in only one of six experiments, while Bandrowski's base (BB), a metabolization product of PPDA induced a significant T-cell response in all six experiments. Conclusion The present in vitro model allows discrimination between two groups of substances: strong contact sensitizers (TNP, FITC. BB) on the one hand and weak sensitizers (coumarin, citronellal and hydroxycitronellal) and irritants (SDS) on the other hand. It could be used as a screening in vitro assay to eliminate strong contact allergens before further predictive animal tests have to be performed." @default.
• W2113402877 created "2016-06-24" @default.
• W2113402877 creator A5016357498 @default.
• W2113402877 creator A5024343613 @default.
• W2113402877 creator A5043641935 @default.
• W2113402877 creator A5050720725 @default.
• W2113402877 creator A5062748268 @default.
• W2113402877 creator A5064669669 @default.
• W2113402877 date "1996-05-01" @default.
• W2113402877 modified "2023-10-12" @default.
• W2113402877 title "<i>In vitro</i>primary sensitization of hapten-specific T cells by cultured human epidermal Langerhans cells-a screening predictive assay for contact sensitizers" @default.
• W2113402877 cites W1510470032 @default.
• W2113402877 cites W1548317256 @default.
• W2113402877 cites W1753071495 @default.
• W2113402877 cites W1971503885 @default.
• W2113402877 cites W1995066128 @default.
• W2113402877 cites W1996948409 @default.
• W2113402877 cites W2009914165 @default.
• W2113402877 cites W2010350911 @default.
• W2113402877 cites W2012814550 @default.
• W2113402877 cites W2013113656 @default.
• W2113402877 cites W2021921824 @default.
• W2113402877 cites W2026258413 @default.
• W2113402877 cites W2038681076 @default.
• W2113402877 cites W2040548366 @default.
• W2113402877 cites W2042033593 @default.
• W2113402877 cites W2047594937 @default.
• W2113402877 cites W2050735843 @default.
• W2113402877 cites W2058832208 @default.
• W2113402877 cites W2062830954 @default.
• W2113402877 cites W2081367101 @default.
• W2113402877 cites W2093348969 @default.
• W2113402877 cites W2096152012 @default.
• W2113402877 cites W2111885152 @default.
• W2113402877 cites W2120987583 @default.
• W2113402877 cites W2137621705 @default.
• W2113402877 cites W2141674316 @default.
• W2113402877 cites W2177327503 @default.
• W2113402877 cites W2912729716 @default.
• W2113402877 cites W3021627084 @default.
• W2113402877 cites W4301141298 @default.
• W2113402877 doi "https://doi.org/10.1111/j.1365-2222.1996.tb00577.x" @default.
• W2113402877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8735869" @default.
• W2113402877 hasPublicationYear "1996" @default.
• W2113402877 type Work @default.
• W2113402877 sameAs 2113402877 @default.
• W2113402877 citedByCount "60" @default.
• W2113402877 countsByYear W21134028772012 @default.
• W2113402877 countsByYear W21134028772013 @default.
• W2113402877 countsByYear W21134028772017 @default.
• W2113402877 countsByYear W21134028772018 @default.
• W2113402877 countsByYear W21134028772019 @default.
• W2113402877 crossrefType "journal-article" @default.
• W2113402877 hasAuthorship W2113402877A5016357498 @default.
• W2113402877 hasAuthorship W2113402877A5024343613 @default.
• W2113402877 hasAuthorship W2113402877A5043641935 @default.
• W2113402877 hasAuthorship W2113402877A5050720725 @default.
• W2113402877 hasAuthorship W2113402877A5062748268 @default.
• W2113402877 hasAuthorship W2113402877A5064669669 @default.
• W2113402877 hasConcept C121332964 @default.
• W2113402877 hasConcept C147483822 @default.
• W2113402877 hasConcept C150903083 @default.
• W2113402877 hasConcept C153911025 @default.
• W2113402877 hasConcept C185592680 @default.
• W2113402877 hasConcept C202751555 @default.
• W2113402877 hasConcept C203014093 @default.
• W2113402877 hasConcept C207001950 @default.
• W2113402877 hasConcept C2776217527 @default.
• W2113402877 hasConcept C2777019933 @default.
• W2113402877 hasConcept C2778015030 @default.
• W2113402877 hasConcept C29144244 @default.
• W2113402877 hasConcept C55493867 @default.
• W2113402877 hasConcept C62520636 @default.
• W2113402877 hasConcept C71924100 @default.
• W2113402877 hasConcept C86803240 @default.
• W2113402877 hasConcept C91881484 @default.
• W2113402877 hasConceptScore W2113402877C121332964 @default.
• W2113402877 hasConceptScore W2113402877C147483822 @default.
• W2113402877 hasConceptScore W2113402877C150903083 @default.
• W2113402877 hasConceptScore W2113402877C153911025 @default.
• W2113402877 hasConceptScore W2113402877C185592680 @default.
• W2113402877 hasConceptScore W2113402877C202751555 @default.
• W2113402877 hasConceptScore W2113402877C203014093 @default.
• W2113402877 hasConceptScore W2113402877C207001950 @default.
• W2113402877 hasConceptScore W2113402877C2776217527 @default.
• W2113402877 hasConceptScore W2113402877C2777019933 @default.
• W2113402877 hasConceptScore W2113402877C2778015030 @default.
• W2113402877 hasConceptScore W2113402877C29144244 @default.
• W2113402877 hasConceptScore W2113402877C55493867 @default.
• W2113402877 hasConceptScore W2113402877C62520636 @default.
• W2113402877 hasConceptScore W2113402877C71924100 @default.
• W2113402877 hasConceptScore W2113402877C86803240 @default.
• W2113402877 hasConceptScore W2113402877C91881484 @default.
• W2113402877 hasIssue "5" @default.
• W2113402877 hasLocation W21134028771 @default.
• W2113402877 hasLocation W21134028772 @default.
• W2113402877 hasOpenAccess W2113402877 @default.
• W2113402877 hasPrimaryLocation W21134028771 @default.

• next