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• W2113403952 startingPage "902" @default.
• W2113403952 abstract "Adoptive T-cell therapy has shown promises for cancer treatment. However, for treating solid tumors, there is a need for improving the ability of the adoptively transferred T cells to home to tumor sites. We explored the possibility of using an oncolytic virus derived from HSV-2, which can actively pull T effector cells to the site of infection, as a local attractant for migration of adoptively transferred T cells. Our data show that intratumoral administration of this virus can indeed attract active migration of the adoptively transferred T cells to the treated tumor. Moreover, once attracted to the tumor site by the virus, T cells persisted in there significantly longer than in mock-treated tumor. Chemokine profiling identified significant elevation of CXCL9 and CXCL10, as well as several other chemokines belonging to the inflammatory chemokine family in the virus-treated tumors. These chemokines initially guided the T-cell migration to and then maintained their persistence in the tumor site, leading to a significantly enhanced therapeutic effect. Our data suggests that this virotherapy may be combined with adoptive T-cell therapy to potentiate its therapeutic effect against solid tumors that are otherwise difficult to manage with the treatment alone." @default.
• W2113403952 created "2016-06-24" @default.
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• W2113403952 creator A5031173987 @default.
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• W2113403952 date "2014-11-25" @default.
• W2113403952 modified "2023-09-26" @default.
• W2113403952 title "An HSV-2 based oncolytic virus can function as an attractant to guide migration of adoptively transferred T cells to tumor sites" @default.
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• W2113403952 doi "https://doi.org/10.18632/oncotarget.2817" @default.
• W2113403952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4359264" @default.
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• W2113403952 hasPublicationYear "2014" @default.
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