FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113405416> ?p ?o ?g. }

• W2113405416 endingPage "952" @default.
• W2113405416 startingPage "947" @default.
• W2113405416 abstract "ABSTRACT To clarify the mechanisms underlying the antiproliferative effects of jasplakinolide, a cyclic depsipeptide from marine sponges, we examined whether jasplakinolide induces apoptosis in a variety of transformed and nontransformed cells. Jasplakinolide inhibited proliferation of human Jurkat T cells, resulting in cell death. This was accompanied by chromatin condensation and DNA cleavage at the linker regions between the nucleosomes. When caspase-3-like activity in the cytosolic extracts of Jurkat T cells was examined with a fluorescent substrate, DEVD-MAC ( N -acetyl-Asp-Glu-Val-Asp-4-methyl-coumaryl-7-amide), the activity in the cells treated with jasplakinolide was remarkably increased in a time-dependent manner. Pretreatment of Jurkat T cells with the caspase inhibitor zVAD [benzyloxycarbonyl(Cbz)-Val-Ala-β-Asp(OMe)-fluoromethylketone] or DEVD-CHO ( N -acetyl-Asp-Glu-Val-Asp-1-aldehyde) prevented the induction of apoptosis by jasplakinolide. Moreover, exposure of various murine transformed cell lines to jasplakinolide resulted in cell death, which was inhibited by zVAD. Although it has been well established that murine immature thymocytes are sensitive to apoptosis when exposed to various apoptotic stimuli, these cells as well as mature T lymphocytes were resistant to jasplakinolide-induced apoptosis. The results suggest that jasplakinolide induces apoptotic cell death through a caspase-3-like protease-dependent pathway. Another important outcome is that transformed cell lines were more susceptible to jasplakinolide-induced apoptosis than normal nontransformed cells." @default.
• W2113405416 created "2016-06-24" @default.
• W2113405416 creator A5049319108 @default.
• W2113405416 creator A5081281541 @default.
• W2113405416 creator A5084098716 @default.
• W2113405416 date "2000-11-01" @default.
• W2113405416 modified "2023-10-15" @default.
• W2113405416 title "Jasplakinolide Induces Apoptosis in Various Transformed Cell Lines by a Caspase-3-Like Protease-Dependent Pathway" @default.
• W2113405416 cites W133599806 @default.
• W2113405416 cites W1560179018 @default.
• W2113405416 cites W171319216 @default.
• W2113405416 cites W1963811956 @default.
• W2113405416 cites W1964072775 @default.
• W2113405416 cites W1966293283 @default.
• W2113405416 cites W1976180978 @default.
• W2113405416 cites W1977198215 @default.
• W2113405416 cites W1981106016 @default.
• W2113405416 cites W1993909690 @default.
• W2113405416 cites W1996931717 @default.
• W2113405416 cites W1998402666 @default.
• W2113405416 cites W2003403462 @default.
• W2113405416 cites W2006930818 @default.
• W2113405416 cites W2011611099 @default.
• W2113405416 cites W2031793205 @default.
• W2113405416 cites W2041193221 @default.
• W2113405416 cites W2041827175 @default.
• W2113405416 cites W2056736540 @default.
• W2113405416 cites W2061497413 @default.
• W2113405416 cites W2062252787 @default.
• W2113405416 cites W2074836458 @default.
• W2113405416 cites W2081145901 @default.
• W2113405416 cites W2084609653 @default.
• W2113405416 cites W2091973156 @default.
• W2113405416 cites W2101402589 @default.
• W2113405416 cites W2101462909 @default.
• W2113405416 cites W2121075882 @default.
• W2113405416 cites W2127380650 @default.
• W2113405416 cites W2132823860 @default.
• W2113405416 cites W2135203140 @default.
• W2113405416 cites W2156179144 @default.
• W2113405416 cites W2163893998 @default.
• W2113405416 cites W2169721137 @default.
• W2113405416 cites W2170070957 @default.
• W2113405416 cites W2953115081 @default.
• W2113405416 doi "https://doi.org/10.1128/cdli.7.6.947-952.2000" @default.
• W2113405416 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/95991" @default.
• W2113405416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11063504" @default.
• W2113405416 hasPublicationYear "2000" @default.
• W2113405416 type Work @default.
• W2113405416 sameAs 2113405416 @default.
• W2113405416 citedByCount "127" @default.
• W2113405416 countsByYear W21134054162012 @default.
• W2113405416 countsByYear W21134054162013 @default.
• W2113405416 countsByYear W21134054162014 @default.
• W2113405416 countsByYear W21134054162015 @default.
• W2113405416 countsByYear W21134054162016 @default.
• W2113405416 countsByYear W21134054162017 @default.
• W2113405416 countsByYear W21134054162018 @default.
• W2113405416 countsByYear W21134054162019 @default.
• W2113405416 countsByYear W21134054162020 @default.
• W2113405416 countsByYear W21134054162021 @default.
• W2113405416 countsByYear W21134054162022 @default.
• W2113405416 countsByYear W21134054162023 @default.
• W2113405416 crossrefType "journal-article" @default.
• W2113405416 hasAuthorship W2113405416A5049319108 @default.
• W2113405416 hasAuthorship W2113405416A5081281541 @default.
• W2113405416 hasAuthorship W2113405416A5084098716 @default.
• W2113405416 hasBestOaLocation W21134054161 @default.
• W2113405416 hasConcept C153911025 @default.
• W2113405416 hasConcept C168831097 @default.
• W2113405416 hasConcept C179464577 @default.
• W2113405416 hasConcept C190283241 @default.
• W2113405416 hasConcept C203014093 @default.
• W2113405416 hasConcept C2776090121 @default.
• W2113405416 hasConcept C31573885 @default.
• W2113405416 hasConcept C54355233 @default.
• W2113405416 hasConcept C55493867 @default.
• W2113405416 hasConcept C81885089 @default.
• W2113405416 hasConcept C86803240 @default.
• W2113405416 hasConcept C8891405 @default.
• W2113405416 hasConcept C95444343 @default.
• W2113405416 hasConcept C98424977 @default.
• W2113405416 hasConceptScore W2113405416C153911025 @default.
• W2113405416 hasConceptScore W2113405416C168831097 @default.
• W2113405416 hasConceptScore W2113405416C179464577 @default.
• W2113405416 hasConceptScore W2113405416C190283241 @default.
• W2113405416 hasConceptScore W2113405416C203014093 @default.
• W2113405416 hasConceptScore W2113405416C2776090121 @default.
• W2113405416 hasConceptScore W2113405416C31573885 @default.
• W2113405416 hasConceptScore W2113405416C54355233 @default.
• W2113405416 hasConceptScore W2113405416C55493867 @default.
• W2113405416 hasConceptScore W2113405416C81885089 @default.
• W2113405416 hasConceptScore W2113405416C86803240 @default.
• W2113405416 hasConceptScore W2113405416C8891405 @default.
• W2113405416 hasConceptScore W2113405416C95444343 @default.
• W2113405416 hasConceptScore W2113405416C98424977 @default.
• W2113405416 hasIssue "6" @default.
• W2113405416 hasLocation W21134054161 @default.

• next