Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113405596> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2113405596 abstract "The phospholipid platelet-activating factor (PAF) (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) stimulated the accumulation of inositol phosphates in cultures of rat and bovine anterior pituitary cells. In response to PAF, inositol 1,4-bisphosphate showed the largest percent increase of the inositol phosphates in the presence of lithium chloride. PAF induced an increase of inositol 1,4,5-trisphosphate, the biologically active isomer responsible for mobilization of intracellular calcium. A characterization of the PAF response indicated that PAF, but not its biologically inactive enantiomer, induced the accumulation of inositol phosphates in the rat anterior pituitary. Further, the PAF receptor antagonist L652731 reduced PAF stimulation. The ED50 for PAF-induced inositol 1,4-bisphosphate accumulation was 0.4 nM. PAF induced a rapid response that did not persist beyond 20 min. While PAF treatment of anterior pituitary cells did not alter TRH-induced inositol phosphate accumulation, it did prevent a second exposure of PAF from inducing inositol phosphate accumulation. These data suggest that PAF induces a rapid stimulation of phospholipase C causing the hydrolysis of phosphatidylinositol 4,5-bisphosphate and the generation of the second messengers, inositol 1,4,5-trisphosphate and diglyceride, in anterior pituitary tissue. This action is transient probably due to PAF receptor desensitization. The action of PAF on generation of inositol phosphates may account, in part, for PAF-induced secretion of PRL and GH." @default.
- W2113405596 created "2016-06-24" @default.
- W2113405596 creator A5066330973 @default.
- W2113405596 date "1990-10-01" @default.
- W2113405596 modified "2023-09-25" @default.
- W2113405596 title "Platelet Activating Factor Induces Inositol Phosphate Accumulation in Cultures of Rat and Bovine Anterior Pituitary Cells*" @default.
- W2113405596 cites W1489515092 @default.
- W2113405596 cites W1494647602 @default.
- W2113405596 cites W1517662067 @default.
- W2113405596 cites W1544535766 @default.
- W2113405596 cites W1571034940 @default.
- W2113405596 cites W1590520398 @default.
- W2113405596 cites W165533631 @default.
- W2113405596 cites W1802980406 @default.
- W2113405596 cites W1998129853 @default.
- W2113405596 cites W2014989485 @default.
- W2113405596 cites W2023198194 @default.
- W2113405596 cites W2031522778 @default.
- W2113405596 cites W2047613580 @default.
- W2113405596 cites W2123771690 @default.
- W2113405596 cites W2173293374 @default.
- W2113405596 cites W2261984195 @default.
- W2113405596 cites W2272451145 @default.
- W2113405596 cites W2314217713 @default.
- W2113405596 cites W2314347700 @default.
- W2113405596 cites W2409762596 @default.
- W2113405596 doi "https://doi.org/10.1210/endo-127-4-1786" @default.
- W2113405596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2169402" @default.
- W2113405596 hasPublicationYear "1990" @default.
- W2113405596 type Work @default.
- W2113405596 sameAs 2113405596 @default.
- W2113405596 citedByCount "10" @default.
- W2113405596 crossrefType "journal-article" @default.
- W2113405596 hasAuthorship W2113405596A5066330973 @default.
- W2113405596 hasConcept C11960822 @default.
- W2113405596 hasConcept C126322002 @default.
- W2113405596 hasConcept C134018914 @default.
- W2113405596 hasConcept C163235415 @default.
- W2113405596 hasConcept C170493617 @default.
- W2113405596 hasConcept C185592680 @default.
- W2113405596 hasConcept C24998067 @default.
- W2113405596 hasConcept C2777427919 @default.
- W2113405596 hasConcept C2778597717 @default.
- W2113405596 hasConcept C2778618036 @default.
- W2113405596 hasConcept C2779020240 @default.
- W2113405596 hasConcept C2779029589 @default.
- W2113405596 hasConcept C2780610907 @default.
- W2113405596 hasConcept C2781387506 @default.
- W2113405596 hasConcept C519063684 @default.
- W2113405596 hasConcept C55493867 @default.
- W2113405596 hasConcept C66135807 @default.
- W2113405596 hasConcept C71315377 @default.
- W2113405596 hasConcept C71924100 @default.
- W2113405596 hasConcept C80631254 @default.
- W2113405596 hasConcept C86803240 @default.
- W2113405596 hasConceptScore W2113405596C11960822 @default.
- W2113405596 hasConceptScore W2113405596C126322002 @default.
- W2113405596 hasConceptScore W2113405596C134018914 @default.
- W2113405596 hasConceptScore W2113405596C163235415 @default.
- W2113405596 hasConceptScore W2113405596C170493617 @default.
- W2113405596 hasConceptScore W2113405596C185592680 @default.
- W2113405596 hasConceptScore W2113405596C24998067 @default.
- W2113405596 hasConceptScore W2113405596C2777427919 @default.
- W2113405596 hasConceptScore W2113405596C2778597717 @default.
- W2113405596 hasConceptScore W2113405596C2778618036 @default.
- W2113405596 hasConceptScore W2113405596C2779020240 @default.
- W2113405596 hasConceptScore W2113405596C2779029589 @default.
- W2113405596 hasConceptScore W2113405596C2780610907 @default.
- W2113405596 hasConceptScore W2113405596C2781387506 @default.
- W2113405596 hasConceptScore W2113405596C519063684 @default.
- W2113405596 hasConceptScore W2113405596C55493867 @default.
- W2113405596 hasConceptScore W2113405596C66135807 @default.
- W2113405596 hasConceptScore W2113405596C71315377 @default.
- W2113405596 hasConceptScore W2113405596C71924100 @default.
- W2113405596 hasConceptScore W2113405596C80631254 @default.
- W2113405596 hasConceptScore W2113405596C86803240 @default.
- W2113405596 hasLocation W21134055961 @default.
- W2113405596 hasLocation W21134055962 @default.
- W2113405596 hasOpenAccess W2113405596 @default.
- W2113405596 hasPrimaryLocation W21134055961 @default.
- W2113405596 hasRelatedWork W1980464838 @default.
- W2113405596 hasRelatedWork W2010677283 @default.
- W2113405596 hasRelatedWork W2035997992 @default.
- W2113405596 hasRelatedWork W2045449591 @default.
- W2113405596 hasRelatedWork W2060288327 @default.
- W2113405596 hasRelatedWork W2091336476 @default.
- W2113405596 hasRelatedWork W2113405596 @default.
- W2113405596 hasRelatedWork W2163437365 @default.
- W2113405596 hasRelatedWork W2220486443 @default.
- W2113405596 hasRelatedWork W2291181753 @default.
- W2113405596 isParatext "false" @default.
- W2113405596 isRetracted "false" @default.
- W2113405596 magId "2113405596" @default.
- W2113405596 workType "article" @default.