FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113405864> ?p ?o ?g. }

• W2113405864 endingPage "2580" @default.
• W2113405864 startingPage "2570" @default.
• W2113405864 abstract "Abstract Purpose: This study aims to address the hypothesis that the high-mobility group A2 (HMGA2), an oncofetal protein, relates to survivability and serves as a prognostic biomarker for colorectal cancer (CRC). Experimental Design: This is a retroprospective multiple center study. The HMGA2 expression level was determined by performing immunohistochemistry on surgical tissue samples of 89 CRCs from a training set and 191 CRCs from a validation set. The Kaplan–Meier analysis and COX proportional hazard model were employed to analyze the survivability. Results: Multivariate logistic analysis indicated that the expression of HMGA2 significantly correlates with distant metastasis in training set (odds ratio, OR = 3.53, 95% CI: 1.37–9.70) and validation set (OR = 6.38, 95% CI: 1.47–43.95). Survival analysis revealed that the overexpression of HMGA2 is significantly associated with poor survival of CRC patients (P &lt; 0.05). The adjusted HRs for overall survival were 2.38 (95% CI: 1.30–4.34) and 2.14 (95% CI: 1.21–3.79) in training and validation sets, respectively. Further investigation revealed that HMGA2 delays the clearance of γ-H2AX in HCT-116 and SW480 cells post γ-irradiation, which supports our finding that CRC patients with HMAG2-positive staining in primary tumors had augmented the efficacy of adjuvant radiotherapy (HR = 0.18, 95% CI: 0.04–0.63). Conclusion: Overexpression of HMGA2 is associated with metastasis and unequivocally occurred in parallel with reduced survival rates of patients with CRC. Therefore, HMGA2 may potentially serve as a biomarker for predicting aggressive CRC with poor survivability and as an indicator for better response of radiotherapy. Clin Cancer Res; 17(8); 2570–80. ©2011 AACR." @default.
• W2113405864 created "2016-06-24" @default.
• W2113405864 creator A5009104622 @default.
• W2113405864 creator A5012995167 @default.
• W2113405864 creator A5018806880 @default.
• W2113405864 creator A5021530808 @default.
• W2113405864 creator A5024529886 @default.
• W2113405864 creator A5027521220 @default.
• W2113405864 creator A5031124433 @default.
• W2113405864 creator A5031383858 @default.
• W2113405864 creator A5039728899 @default.
• W2113405864 creator A5045796734 @default.
• W2113405864 creator A5048401428 @default.
• W2113405864 creator A5050175651 @default.
• W2113405864 creator A5052675433 @default.
• W2113405864 creator A5063372408 @default.
• W2113405864 creator A5076232253 @default.
• W2113405864 creator A5081487015 @default.
• W2113405864 creator A5084717592 @default.
• W2113405864 creator A5091643392 @default.
• W2113405864 date "2011-04-14" @default.
• W2113405864 modified "2023-09-23" @default.
• W2113405864 title "Overexpression of HMGA2 Promotes Metastasis and Impacts Survival of Colorectal Cancers" @default.
• W2113405864 cites W1985530882 @default.
• W2113405864 cites W1990808656 @default.
• W2113405864 cites W1995470161 @default.
• W2113405864 cites W2000343561 @default.
• W2113405864 cites W2002577204 @default.
• W2113405864 cites W2010511984 @default.
• W2113405864 cites W2016136785 @default.
• W2113405864 cites W2020830322 @default.
• W2113405864 cites W2032474685 @default.
• W2113405864 cites W2039471809 @default.
• W2113405864 cites W2039620381 @default.
• W2113405864 cites W2048059402 @default.
• W2113405864 cites W2062586342 @default.
• W2113405864 cites W2079879959 @default.
• W2113405864 cites W2080827304 @default.
• W2113405864 cites W2082072812 @default.
• W2113405864 cites W2093619351 @default.
• W2113405864 cites W2094013368 @default.
• W2113405864 cites W2095845495 @default.
• W2113405864 cites W2097017584 @default.
• W2113405864 cites W2098914161 @default.
• W2113405864 cites W2106670703 @default.
• W2113405864 cites W2131596261 @default.
• W2113405864 cites W2133283301 @default.
• W2113405864 cites W2146783942 @default.
• W2113405864 cites W2148043102 @default.
• W2113405864 cites W2153693413 @default.
• W2113405864 cites W2158734599 @default.
• W2113405864 cites W2170647698 @default.
• W2113405864 cites W2171148163 @default.
• W2113405864 cites W4211147392 @default.
• W2113405864 doi "https://doi.org/10.1158/1078-0432.ccr-10-2542" @default.
• W2113405864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3079060" @default.
• W2113405864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21252160" @default.
• W2113405864 hasPublicationYear "2011" @default.
• W2113405864 type Work @default.
• W2113405864 sameAs 2113405864 @default.
• W2113405864 citedByCount "155" @default.
• W2113405864 countsByYear W21134058642012 @default.
• W2113405864 countsByYear W21134058642013 @default.
• W2113405864 countsByYear W21134058642014 @default.
• W2113405864 countsByYear W21134058642015 @default.
• W2113405864 countsByYear W21134058642016 @default.
• W2113405864 countsByYear W21134058642017 @default.
• W2113405864 countsByYear W21134058642018 @default.
• W2113405864 countsByYear W21134058642019 @default.
• W2113405864 countsByYear W21134058642020 @default.
• W2113405864 countsByYear W21134058642021 @default.
• W2113405864 countsByYear W21134058642022 @default.
• W2113405864 countsByYear W21134058642023 @default.
• W2113405864 crossrefType "journal-article" @default.
• W2113405864 hasAuthorship W2113405864A5009104622 @default.
• W2113405864 hasAuthorship W2113405864A5012995167 @default.
• W2113405864 hasAuthorship W2113405864A5018806880 @default.
• W2113405864 hasAuthorship W2113405864A5021530808 @default.
• W2113405864 hasAuthorship W2113405864A5024529886 @default.
• W2113405864 hasAuthorship W2113405864A5027521220 @default.
• W2113405864 hasAuthorship W2113405864A5031124433 @default.
• W2113405864 hasAuthorship W2113405864A5031383858 @default.
• W2113405864 hasAuthorship W2113405864A5039728899 @default.
• W2113405864 hasAuthorship W2113405864A5045796734 @default.
• W2113405864 hasAuthorship W2113405864A5048401428 @default.
• W2113405864 hasAuthorship W2113405864A5050175651 @default.
• W2113405864 hasAuthorship W2113405864A5052675433 @default.
• W2113405864 hasAuthorship W2113405864A5063372408 @default.
• W2113405864 hasAuthorship W2113405864A5076232253 @default.
• W2113405864 hasAuthorship W2113405864A5081487015 @default.
• W2113405864 hasAuthorship W2113405864A5084717592 @default.
• W2113405864 hasAuthorship W2113405864A5091643392 @default.
• W2113405864 hasBestOaLocation W21134058641 @default.
• W2113405864 hasConcept C104317684 @default.
• W2113405864 hasConcept C10515644 @default.
• W2113405864 hasConcept C121608353 @default.
• W2113405864 hasConcept C126322002 @default.
• W2113405864 hasConcept C143998085 @default.

• next