Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113425624> ?p ?o ?g. }
- W2113425624 endingPage "1636" @default.
- W2113425624 startingPage "1627" @default.
- W2113425624 abstract "Small interfering RNAs (siRNA) are emerging as novel therapeutic agents, providing competent delivery systems that are available. Dendrimers, a special family of synthetic macromolecules, represent an exciting delivery platform by virtue of their well-defined dendritic structure and unique multivalency and cooperativity confined within a nanoscale volume. Here, we report a Dicer-substrate siRNA (dsiRNA) which, when delivered using a structurally flexible triethanolamine-core poly(amidoamine) dendrimer of generation 5 as the nanocarrier, gives rise to a much greater RNAi response than that produced with conventional siRNA. Further decoration of the dsiRNA/dendrimer complexes with a dual targeting peptide simultaneously promoted cancer cell targeting through interacting with integrins and cell penetration via the interaction with neuropilin-1 receptors, which led to improved gene silencing and anticancer activity. Altogether, our results disclosed here open a new avenue for therapeutic implementation of RNAi using dendrimer nanovector based targeted delivery. This study demonstrates superior therapeutic properties of siRNA when combined with a dendrimer-based targeted nano-delivery system. Similar approaches may eventually gain clinical utility following additional studies determining safety and efficacy." @default.
- W2113425624 created "2016-06-24" @default.
- W2113425624 creator A5002659900 @default.
- W2113425624 creator A5033030924 @default.
- W2113425624 creator A5042026897 @default.
- W2113425624 creator A5056248574 @default.
- W2113425624 creator A5058939867 @default.
- W2113425624 creator A5064510604 @default.
- W2113425624 creator A5074399549 @default.
- W2113425624 creator A5084164786 @default.
- W2113425624 creator A5088964722 @default.
- W2113425624 date "2014-11-01" @default.
- W2113425624 modified "2023-09-27" @default.
- W2113425624 title "Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system" @default.
- W2113425624 cites W1647075334 @default.
- W2113425624 cites W1964146045 @default.
- W2113425624 cites W1969457012 @default.
- W2113425624 cites W1974136307 @default.
- W2113425624 cites W1974891955 @default.
- W2113425624 cites W1979020916 @default.
- W2113425624 cites W1980461289 @default.
- W2113425624 cites W1986301359 @default.
- W2113425624 cites W1989658253 @default.
- W2113425624 cites W1996181208 @default.
- W2113425624 cites W1996609303 @default.
- W2113425624 cites W1998074678 @default.
- W2113425624 cites W2001018320 @default.
- W2113425624 cites W2005202590 @default.
- W2113425624 cites W2025344276 @default.
- W2113425624 cites W2025708633 @default.
- W2113425624 cites W2034710772 @default.
- W2113425624 cites W2034739637 @default.
- W2113425624 cites W2040607554 @default.
- W2113425624 cites W2042929078 @default.
- W2113425624 cites W2049233124 @default.
- W2113425624 cites W2050238491 @default.
- W2113425624 cites W2069904748 @default.
- W2113425624 cites W2074161384 @default.
- W2113425624 cites W2080459765 @default.
- W2113425624 cites W2083061567 @default.
- W2113425624 cites W2114788766 @default.
- W2113425624 cites W2116424844 @default.
- W2113425624 cites W2119887420 @default.
- W2113425624 cites W2120343044 @default.
- W2113425624 cites W2138708625 @default.
- W2113425624 cites W2143416316 @default.
- W2113425624 cites W2147000598 @default.
- W2113425624 cites W2158734599 @default.
- W2113425624 cites W2163326536 @default.
- W2113425624 cites W2168927463 @default.
- W2113425624 cites W2170255011 @default.
- W2113425624 cites W2244319654 @default.
- W2113425624 cites W2299028002 @default.
- W2113425624 cites W2314133652 @default.
- W2113425624 cites W2321236765 @default.
- W2113425624 cites W2323792247 @default.
- W2113425624 cites W2333945947 @default.
- W2113425624 cites W2412431453 @default.
- W2113425624 cites W2583230376 @default.
- W2113425624 cites W35622968 @default.
- W2113425624 cites W4211039187 @default.
- W2113425624 doi "https://doi.org/10.1016/j.nano.2014.05.008" @default.
- W2113425624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24965758" @default.
- W2113425624 hasPublicationYear "2014" @default.
- W2113425624 type Work @default.
- W2113425624 sameAs 2113425624 @default.
- W2113425624 citedByCount "42" @default.
- W2113425624 countsByYear W21134256242015 @default.
- W2113425624 countsByYear W21134256242016 @default.
- W2113425624 countsByYear W21134256242017 @default.
- W2113425624 countsByYear W21134256242018 @default.
- W2113425624 countsByYear W21134256242019 @default.
- W2113425624 countsByYear W21134256242020 @default.
- W2113425624 countsByYear W21134256242021 @default.
- W2113425624 countsByYear W21134256242022 @default.
- W2113425624 countsByYear W21134256242023 @default.
- W2113425624 crossrefType "journal-article" @default.
- W2113425624 hasAuthorship W2113425624A5002659900 @default.
- W2113425624 hasAuthorship W2113425624A5033030924 @default.
- W2113425624 hasAuthorship W2113425624A5042026897 @default.
- W2113425624 hasAuthorship W2113425624A5056248574 @default.
- W2113425624 hasAuthorship W2113425624A5058939867 @default.
- W2113425624 hasAuthorship W2113425624A5064510604 @default.
- W2113425624 hasAuthorship W2113425624A5074399549 @default.
- W2113425624 hasAuthorship W2113425624A5084164786 @default.
- W2113425624 hasAuthorship W2113425624A5088964722 @default.
- W2113425624 hasConcept C104317684 @default.
- W2113425624 hasConcept C119056186 @default.
- W2113425624 hasConcept C135983454 @default.
- W2113425624 hasConcept C166703698 @default.
- W2113425624 hasConcept C171250308 @default.
- W2113425624 hasConcept C18150654 @default.
- W2113425624 hasConcept C185592680 @default.
- W2113425624 hasConcept C192562407 @default.
- W2113425624 hasConcept C22615655 @default.
- W2113425624 hasConcept C2779820397 @default.
- W2113425624 hasConcept C2779867133 @default.
- W2113425624 hasConcept C54009773 @default.