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- W2113427314 abstract "We investigated the effect of bradykinin (BK) on isolated equine basilar arterial rings with and without endothelium. BK induced concentration‐dependent contraction of resting arterial rings and no relaxation when the rings were precontracted by prostaglandin F 2α . The maximal response and pD 2 value were 161.2 ± 28.1% (to 60 m m KCl‐induced contraction) and 8.24 ± 0.25 respectively. The cumulative concentration–response curve for BK was not shifted to the right by des‐Arg 9 ‐[Leu 8 ]‐BK (a B 1 ‐receptor antagonist), HOE140 (a B 2 ‐receptor antagonist) or NPC567 (another B 2 ‐receptor antagonist). In four of six basilar arteries, NPC567 induced concentration‐dependent contraction. Indomethacin (a cyclooxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), quinacrine (a phospholipase A 2 inhibitor), tetrodotoxin (a selective blocker of Na + channels), guanethidine (a nor‐adrenergic neuron blocking drug), phentolamine (an α‐adrenoceptor antagonist), Nω‐nitro‐ l ‐arginine ( l ‐NNA, a nitric oxide (NO) synthase inhibitor) and endothelial denudation did not affect the BK‐induced contraction. l ‐NNA and indomethacin induced contraction and relaxation under resting vascular tone respectively. These results suggest that endothelial cells are not involved in BK‐induced contraction and that the contraction is not mediated via activation of known B 1 and B 2 receptors. Arachidonic acid metabolites and neurotransmitters like norepinephrine and NO might not play a role in BK‐induced contraction in equine basilar artery." @default.
- W2113427314 created "2016-06-24" @default.
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- W2113427314 date "2009-05-19" @default.
- W2113427314 modified "2023-10-18" @default.
- W2113427314 title "Characterization of bradykinin-induced endothelium-independent contraction in equine basilar artery" @default.
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- W2113427314 doi "https://doi.org/10.1111/j.1365-2885.2008.01037.x" @default.
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