Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113428279> ?p ?o ?g. }
- W2113428279 endingPage "6256" @default.
- W2113428279 startingPage "6248" @default.
- W2113428279 abstract "We have previously demonstrated that a transcriptional arrest site exists in exon 1 of the human adenosine deaminase (ADA) gene and that this site may play a role in ADA gene expression (Z. Chen, M. L. Harless, D. A. Wright, and R. E. Kellems, Mol. Cell. Biol. 10:4555-4564, 1990). Sequences involved in this process are not known precisely. To further define the template requirements for transcriptional arrest within exon 1 of the human ADA gene, various ADA templates were constructed and their abilities to confer transcriptional arrest were determined following injection into Xenopus oocytes. The exon 1 transcriptional arrest signal functioned downstream of several RNA polymerase II promoters and an RNA polymerase III promoter, implying that the transcriptional arrest site in exon 1 of the ADA gene is promoter independent. We identified a 43-bp DNA fragment which functions as a transcriptional arrest signal. Additional studies showed that the transcriptional arrest site functioned only in the naturally occurring orientation. Therefore, we have identified a 43-bp DNA fragment which functions as a transcriptional arrest signal in an orientation-dependent and promoter-independent manner. On the basis of our findings, we hypothesize that tissue-specific expression of the ADA gene is governed by factors that function as antiterminators to promote transcriptional readthrough of the exon 1 transcriptional arrest site." @default.
- W2113428279 created "2016-06-24" @default.
- W2113428279 creator A5006325126 @default.
- W2113428279 creator A5008276506 @default.
- W2113428279 creator A5062484602 @default.
- W2113428279 creator A5065051008 @default.
- W2113428279 creator A5071174154 @default.
- W2113428279 date "1991-12-01" @default.
- W2113428279 modified "2023-10-14" @default.
- W2113428279 title "Sequence requirements for transcriptional arrest in exon 1 of the human adenosine deaminase gene." @default.
- W2113428279 cites W1411639921 @default.
- W2113428279 cites W1490621345 @default.
- W2113428279 cites W1492241472 @default.
- W2113428279 cites W1495272934 @default.
- W2113428279 cites W1526645657 @default.
- W2113428279 cites W1570974013 @default.
- W2113428279 cites W1574548557 @default.
- W2113428279 cites W1588529304 @default.
- W2113428279 cites W1749218762 @default.
- W2113428279 cites W1767829943 @default.
- W2113428279 cites W1782899195 @default.
- W2113428279 cites W1823053742 @default.
- W2113428279 cites W1837120183 @default.
- W2113428279 cites W1838501880 @default.
- W2113428279 cites W1843768908 @default.
- W2113428279 cites W1844500634 @default.
- W2113428279 cites W1858778292 @default.
- W2113428279 cites W1953380675 @default.
- W2113428279 cites W1955315442 @default.
- W2113428279 cites W1955369670 @default.
- W2113428279 cites W1971746217 @default.
- W2113428279 cites W1978539107 @default.
- W2113428279 cites W1983375834 @default.
- W2113428279 cites W1989313376 @default.
- W2113428279 cites W1994203510 @default.
- W2113428279 cites W1996164869 @default.
- W2113428279 cites W1997184987 @default.
- W2113428279 cites W2015238489 @default.
- W2113428279 cites W2019895401 @default.
- W2113428279 cites W2023437882 @default.
- W2113428279 cites W2023491365 @default.
- W2113428279 cites W2025763720 @default.
- W2113428279 cites W2026539172 @default.
- W2113428279 cites W2028323670 @default.
- W2113428279 cites W2040302336 @default.
- W2113428279 cites W2040542401 @default.
- W2113428279 cites W2047043554 @default.
- W2113428279 cites W2050797066 @default.
- W2113428279 cites W2053314403 @default.
- W2113428279 cites W2062645059 @default.
- W2113428279 cites W2064598758 @default.
- W2113428279 cites W2069665067 @default.
- W2113428279 cites W2070986209 @default.
- W2113428279 cites W2072916562 @default.
- W2113428279 cites W2072973625 @default.
- W2113428279 cites W2076358456 @default.
- W2113428279 cites W2077463064 @default.
- W2113428279 cites W2078119356 @default.
- W2113428279 cites W2081260818 @default.
- W2113428279 cites W2086584161 @default.
- W2113428279 cites W2086967977 @default.
- W2113428279 cites W2087646866 @default.
- W2113428279 cites W2087844645 @default.
- W2113428279 cites W2105933640 @default.
- W2113428279 cites W2111954586 @default.
- W2113428279 cites W2113207529 @default.
- W2113428279 cites W2127190901 @default.
- W2113428279 cites W2130470154 @default.
- W2113428279 cites W2134197157 @default.
- W2113428279 cites W2134812217 @default.
- W2113428279 cites W2138762386 @default.
- W2113428279 cites W2142942720 @default.
- W2113428279 cites W2275798016 @default.
- W2113428279 cites W2293525090 @default.
- W2113428279 cites W2297087120 @default.
- W2113428279 cites W2414945235 @default.
- W2113428279 cites W37841377 @default.
- W2113428279 cites W54416263 @default.
- W2113428279 doi "https://doi.org/10.1128/mcb.11.12.6248" @default.
- W2113428279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/362251" @default.
- W2113428279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1944287" @default.
- W2113428279 hasPublicationYear "1991" @default.
- W2113428279 type Work @default.
- W2113428279 sameAs 2113428279 @default.
- W2113428279 citedByCount "26" @default.
- W2113428279 crossrefType "journal-article" @default.
- W2113428279 hasAuthorship W2113428279A5006325126 @default.
- W2113428279 hasAuthorship W2113428279A5008276506 @default.
- W2113428279 hasAuthorship W2113428279A5062484602 @default.
- W2113428279 hasAuthorship W2113428279A5065051008 @default.
- W2113428279 hasAuthorship W2113428279A5071174154 @default.
- W2113428279 hasBestOaLocation W21134282792 @default.
- W2113428279 hasConcept C101762097 @default.
- W2113428279 hasConcept C104317684 @default.
- W2113428279 hasConcept C150194340 @default.
- W2113428279 hasConcept C153911025 @default.
- W2113428279 hasConcept C165864922 @default.
- W2113428279 hasConcept C27153228 @default.