Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113429643> ?p ?o ?g. }
- W2113429643 endingPage "1145" @default.
- W2113429643 startingPage "1136" @default.
- W2113429643 abstract "Hypothalamic production of growth hormone releasing hormone stimulates the anterior pituitary gland to release growth hormone (GH). The clinical manifestations of GH on tissues are either direct or are mediated by insulin-like growth factors (IGF). Both the somatic effects of GH and the renal manifestations of an increase in glomerular filtration rate and renal plasma flow are mediated by IGF. The increase in glomerular filtration rate/renal plasma flow that occurs with either exogenous or endogenous GH is not apparent in patients with chronic renal failure (CRF); therefore, it is unlikely that recombinant human growth hormone (rhGH) treatment of patients with CRF will result in glomerular hyperfiltration. Longitudinal studies are required to determine if the glomerulosclerosis and renal functional impairment occurring in GH and growth hormone releasing hormone transgenic mice occurs after rhGH treatment of growth-retarded uremic rats with GH resulted in an improvement in growth velocity. This led to preliminary studies in growth-retarded children with CRF by using rhGH. The acceleration of growth velocity was dramatic despite the fact that GH levels are elevated in uremia. The elevated IGF carrier proteins in uremic children may contribute to the growth retardation. Treatment with rhGH may be efficacious by stimulating a net increase in the free (unbound) IGF levels. Hyposecretion of GH may contribute to the failure to achieve optimal growth after successful renal transplantation. Treatment with rhGH may be efficacious in improving the growth velocity of renal allograft recipients." @default.
- W2113429643 created "2016-06-24" @default.
- W2113429643 creator A5031147524 @default.
- W2113429643 date "1991-04-01" @default.
- W2113429643 modified "2023-10-16" @default.
- W2113429643 title "Growth hormone and the kidney" @default.
- W2113429643 cites W105305041 @default.
- W2113429643 cites W1963584943 @default.
- W2113429643 cites W1965916596 @default.
- W2113429643 cites W1966917914 @default.
- W2113429643 cites W1968820992 @default.
- W2113429643 cites W1973144860 @default.
- W2113429643 cites W1973378537 @default.
- W2113429643 cites W1973416718 @default.
- W2113429643 cites W1973504718 @default.
- W2113429643 cites W1977226814 @default.
- W2113429643 cites W1979887033 @default.
- W2113429643 cites W1982844259 @default.
- W2113429643 cites W1983221409 @default.
- W2113429643 cites W1991836807 @default.
- W2113429643 cites W1992540351 @default.
- W2113429643 cites W1993200234 @default.
- W2113429643 cites W1996109554 @default.
- W2113429643 cites W2007726262 @default.
- W2113429643 cites W2016186437 @default.
- W2113429643 cites W2016422210 @default.
- W2113429643 cites W2017272790 @default.
- W2113429643 cites W2018613256 @default.
- W2113429643 cites W2021930415 @default.
- W2113429643 cites W2023644244 @default.
- W2113429643 cites W2026050417 @default.
- W2113429643 cites W2029906341 @default.
- W2113429643 cites W2030383062 @default.
- W2113429643 cites W2033636509 @default.
- W2113429643 cites W2034230657 @default.
- W2113429643 cites W2035980860 @default.
- W2113429643 cites W2042089677 @default.
- W2113429643 cites W2042205189 @default.
- W2113429643 cites W2047613985 @default.
- W2113429643 cites W2048662407 @default.
- W2113429643 cites W2054764016 @default.
- W2113429643 cites W2055401140 @default.
- W2113429643 cites W2056799644 @default.
- W2113429643 cites W2062221617 @default.
- W2113429643 cites W2062923771 @default.
- W2113429643 cites W2065879561 @default.
- W2113429643 cites W2066365517 @default.
- W2113429643 cites W2070995741 @default.
- W2113429643 cites W2073265842 @default.
- W2113429643 cites W2077730853 @default.
- W2113429643 cites W2084037051 @default.
- W2113429643 cites W2091204956 @default.
- W2113429643 cites W2091402854 @default.
- W2113429643 cites W2102123572 @default.
- W2113429643 cites W2110321634 @default.
- W2113429643 cites W2122330920 @default.
- W2113429643 cites W2123271987 @default.
- W2113429643 cites W2127334978 @default.
- W2113429643 cites W2134109634 @default.
- W2113429643 cites W2136656463 @default.
- W2113429643 cites W2138451050 @default.
- W2113429643 cites W2159274656 @default.
- W2113429643 cites W2168234252 @default.
- W2113429643 cites W2288699169 @default.
- W2113429643 cites W2385304589 @default.
- W2113429643 cites W2405463745 @default.
- W2113429643 cites W2419095900 @default.
- W2113429643 cites W2460122282 @default.
- W2113429643 cites W2463325760 @default.
- W2113429643 cites W345492676 @default.
- W2113429643 cites W2411678831 @default.
- W2113429643 cites W2535307154 @default.
- W2113429643 doi "https://doi.org/10.1681/asn.v1101136" @default.
- W2113429643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1768809" @default.
- W2113429643 hasPublicationYear "1991" @default.
- W2113429643 type Work @default.
- W2113429643 sameAs 2113429643 @default.
- W2113429643 citedByCount "21" @default.
- W2113429643 countsByYear W21134296432012 @default.
- W2113429643 countsByYear W21134296432015 @default.
- W2113429643 countsByYear W21134296432022 @default.
- W2113429643 crossrefType "journal-article" @default.
- W2113429643 hasAuthorship W2113429643A5031147524 @default.
- W2113429643 hasBestOaLocation W21134296431 @default.
- W2113429643 hasConcept C126322002 @default.
- W2113429643 hasConcept C134018914 @default.
- W2113429643 hasConcept C142225936 @default.
- W2113429643 hasConcept C159641895 @default.
- W2113429643 hasConcept C2777390665 @default.
- W2113429643 hasConcept C2778135454 @default.
- W2113429643 hasConcept C2779561371 @default.
- W2113429643 hasConcept C2780091579 @default.
- W2113429643 hasConcept C2911091166 @default.
- W2113429643 hasConcept C2984496839 @default.
- W2113429643 hasConcept C71315377 @default.
- W2113429643 hasConcept C71924100 @default.
- W2113429643 hasConceptScore W2113429643C126322002 @default.
- W2113429643 hasConceptScore W2113429643C134018914 @default.