Matches in SemOpenAlex for { <https://semopenalex.org/work/W2113430679> ?p ?o ?g. }
- W2113430679 endingPage "651" @default.
- W2113430679 startingPage "646" @default.
- W2113430679 abstract "The high incidence of erectile dysfunction (ED) in diabetes highlights a need for effective treatment strategies. Resveratrol, an activator of silent information regulator 2-related enzymes 1 (sirtuin1, SIRT1), has received attention for its valuable effects in cancer, neurodegenerative diseases, longevity and cardiovascular disease. To explore the effects of resveratrol in diabetes-induced ED, resveratrol was administered to rats with streptozocin (65 mg kg(-1))-induced diabetes. Erectile function, cavernous structure, tissue protein expression of silent information regulator 2-related enzymes 1 (sirtuin1, SIRT1), p53 and forkhead transcription factor O 3a (FOXO3a), superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels in the corpora cavernosa were studied. We found that SIRT1 was expressed in cavernosal tissue, and it was downregulated in the corpora of diabetic rats. The administration of resveratrol upregulated the expression of SIRT1 and restored erectile function. In contrast, resveratrol downregulated the expression of p53 and FOXO3a, which regulate apoptosis and oxidative stress. Furthermore, the resveratrol-treated group showed an improvement in smooth muscle content, SOD activity and MDA levels when compared with the diabetic group. Therefore, the ability of resveratrol to improve diabetes-induced ED is likely related to its activation of SIRT1 expression, thus causing the suppression of apoptosis and resistance towards oxidative stress." @default.
- W2113430679 created "2016-06-24" @default.
- W2113430679 creator A5001047616 @default.
- W2113430679 creator A5006322525 @default.
- W2113430679 creator A5061402622 @default.
- W2113430679 creator A5071198673 @default.
- W2113430679 creator A5087369634 @default.
- W2113430679 date "2013-06-24" @default.
- W2113430679 modified "2023-10-17" @default.
- W2113430679 title "Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats" @default.
- W2113430679 cites W1493846190 @default.
- W2113430679 cites W1857031680 @default.
- W2113430679 cites W1967789824 @default.
- W2113430679 cites W1978778821 @default.
- W2113430679 cites W1993519646 @default.
- W2113430679 cites W1995175684 @default.
- W2113430679 cites W1995188356 @default.
- W2113430679 cites W2004211520 @default.
- W2113430679 cites W2012753961 @default.
- W2113430679 cites W2016645610 @default.
- W2113430679 cites W2022416092 @default.
- W2113430679 cites W2035543709 @default.
- W2113430679 cites W2053047722 @default.
- W2113430679 cites W2054193823 @default.
- W2113430679 cites W2054447845 @default.
- W2113430679 cites W2060814375 @default.
- W2113430679 cites W2063057213 @default.
- W2113430679 cites W2064079175 @default.
- W2113430679 cites W2074439614 @default.
- W2113430679 cites W2074584000 @default.
- W2113430679 cites W2088307208 @default.
- W2113430679 cites W2096342326 @default.
- W2113430679 cites W2099364141 @default.
- W2113430679 cites W2099806958 @default.
- W2113430679 cites W2104999225 @default.
- W2113430679 cites W2106934996 @default.
- W2113430679 cites W2111473763 @default.
- W2113430679 cites W2116350182 @default.
- W2113430679 cites W2117499294 @default.
- W2113430679 cites W2120007830 @default.
- W2113430679 cites W2124595934 @default.
- W2113430679 cites W2124898423 @default.
- W2113430679 cites W2128737073 @default.
- W2113430679 cites W2133959309 @default.
- W2113430679 cites W2135603240 @default.
- W2113430679 cites W2135783745 @default.
- W2113430679 cites W2140745366 @default.
- W2113430679 cites W2158124286 @default.
- W2113430679 cites W2161440623 @default.
- W2113430679 cites W2165722123 @default.
- W2113430679 cites W2170970016 @default.
- W2113430679 cites W2171391341 @default.
- W2113430679 doi "https://doi.org/10.1038/aja.2013.60" @default.
- W2113430679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3881649" @default.
- W2113430679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23792339" @default.
- W2113430679 hasPublicationYear "2013" @default.
- W2113430679 type Work @default.
- W2113430679 sameAs 2113430679 @default.
- W2113430679 citedByCount "54" @default.
- W2113430679 countsByYear W21134306792013 @default.
- W2113430679 countsByYear W21134306792014 @default.
- W2113430679 countsByYear W21134306792015 @default.
- W2113430679 countsByYear W21134306792016 @default.
- W2113430679 countsByYear W21134306792017 @default.
- W2113430679 countsByYear W21134306792018 @default.
- W2113430679 countsByYear W21134306792019 @default.
- W2113430679 countsByYear W21134306792020 @default.
- W2113430679 countsByYear W21134306792021 @default.
- W2113430679 countsByYear W21134306792022 @default.
- W2113430679 countsByYear W21134306792023 @default.
- W2113430679 crossrefType "journal-article" @default.
- W2113430679 hasAuthorship W2113430679A5001047616 @default.
- W2113430679 hasAuthorship W2113430679A5006322525 @default.
- W2113430679 hasAuthorship W2113430679A5061402622 @default.
- W2113430679 hasAuthorship W2113430679A5071198673 @default.
- W2113430679 hasAuthorship W2113430679A5087369634 @default.
- W2113430679 hasBestOaLocation W21134306791 @default.
- W2113430679 hasConcept C104317684 @default.
- W2113430679 hasConcept C126322002 @default.
- W2113430679 hasConcept C127561419 @default.
- W2113430679 hasConcept C134018914 @default.
- W2113430679 hasConcept C140149449 @default.
- W2113430679 hasConcept C170493617 @default.
- W2113430679 hasConcept C190283241 @default.
- W2113430679 hasConcept C2775838275 @default.
- W2113430679 hasConcept C2776151105 @default.
- W2113430679 hasConcept C2776536020 @default.
- W2113430679 hasConcept C2776816829 @default.
- W2113430679 hasConcept C2778401633 @default.
- W2113430679 hasConcept C2779280383 @default.
- W2113430679 hasConcept C2779929075 @default.
- W2113430679 hasConcept C55493867 @default.
- W2113430679 hasConcept C555293320 @default.
- W2113430679 hasConcept C71924100 @default.
- W2113430679 hasConcept C75217442 @default.
- W2113430679 hasConcept C86803240 @default.
- W2113430679 hasConcept C88045685 @default.
- W2113430679 hasConcept C98274493 @default.