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• W2113431961 abstract "Four more years! This simple tweet, showing a photo of the U. S. President embracing his wife, surpassed 500,000 re-tweets and became one of the most re-tweeted posts of all times [1]. Considering that it is now 6 years since Haissaguerre et al. [2], Nam et al. [3], and our group [4] demonstrated a statistically significant association between early repolarization and the risk for idiopathic ventricular fibrillation (VF), it is timely to ask if the first 6 years of intense investigation of this phenomenon—nicely reviewed by Huikuri and Junttila [5] in this issue of Trends in Cardiovascular Medicine—will continue with the same impetus for 6 more years. The authors of the present review, a proliferous group at the University of Oulu in Finland, deserve the credit for establishing for the first time, in a large population-based study, that ostensibly healthy adults who have early repolarization in their electrocardiogram (ECG) are at an increased risk for dying suddenly during long-term follow-up [6]. Interestingly, the first author in that study, Jani Tikkanen, was a medical student when he reviewed the 10,864 ECGs of this project as part of his MD thesis...not bad for a study eventually published in the New England Journal of Medicine [6]. To complete that project, Jani flew every weekend from Oulu to Helsinki and literally slept over in the ECG review room, a formidable story worth mentioning to all graduating students. The Finnish study [6] was reproduced by 8 more studies within a 5-year period, presenting cumulative data for 430,000 subjects and nearly 1-million person-years of follow-up [7]. Although these studies presented conflicting evidence regarding the effects of early repolarization on total mortality, all studies with available data agreed that the longterm risk of arrhythmic death risk is increased for individuals with early repolarization [7]. Furthermore, the prolific group" @default.
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• W2113431961 date "2015-01-01" @default.
• W2113431961 modified "2023-09-27" @default.
• W2113431961 title "Early repolarization and arrhythmic death: Six more years?" @default.
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• W2113431961 doi "https://doi.org/10.1016/j.tcm.2014.09.008" @default.
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