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- W2113433187 abstract "A interacao entre a droga anti-depressiva, sertralina, com o DNA de fita dupla (dsDNA) de timo de vitelo em tampao fisiologico (pH 7,4) foi determinada por espectrofotometria de UV-Vis, espectrofluorimetria, dicroismo circular, espectroscopia no infravermelho com transformada de Fourier (FTIR), medicoes da viscosidade e estudos de fusao de DNA. Os espectros de absorcao da droga com o DNA mostraram um efeito hipercromico. Ao usar o reagente Hoechst como uma sonda de fluorescencia ocorreu a extincao do pico de emissao na mistura DNA-Hoechst apos a adicao da sertralina. Os espectros de FTIR revelaram o modo de ligacao de menor sulco entre o farmaco e o dsDNA. A constante de ligacao da sertralina ao DNA foi calculada utilizando os dados espectroscopicos. Os parâmetros termodinâmicos calculados sugeriram que as interacoes eletrostaticas sao forcas importantes na formacao do complexo DNA-sertralina. The interaction of the antidepressant drug, sertraline, with calf thymus double stranded DNA (dsDNA) in physiological buffer (pH 7.4) was investigated by UV-Vis spectrophotometry, spectrofluorimetry, circular dichroism, Fourier transform infrared spectroscopy (FTIR), viscosity measurements and DNA melting studies. The absorption spectra of the drug with DNA showed a hyperchromic effect. Using Hoechst reagent as a fluorescence probe, quenching of the emission peak occurred in the DNA-Hoechst mixture when sertraline was added. The FTIR spectra revealed minor groove binding mode between the drug and the dsDNA. The binding constant of sertraline to DNA was calculated using spectroscopic data. The calculated thermodynamic parameters suggested that electrostatic interactions are important forces in the formation of sertraline-DNA complex." @default.
- W2113433187 created "2016-06-24" @default.
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- W2113433187 date "2013-01-01" @default.
- W2113433187 modified "2023-09-26" @default.
- W2113433187 title "Investigation of the Interaction of Sertraline with Calf Thymus DNA by Spectroscopic Methods" @default.
- W2113433187 doi "https://doi.org/10.5935/0103-5053.20130123" @default.
- W2113433187 hasPublicationYear "2013" @default.
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